The pharmacokinetics of ibuprofen after burn injury

J. B. Cone, B. H. Wallace, K. M. Olsen, F. T. Caldwell, B. J. Gurley, P. J. Bond

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Ibuprofen is an effective antipyretic in the postburn period and produces associated decrements in the hypermetabolic response. Burn injury is capable of altering the kinetics of many drugs, making the predictable use of agents such as ibuprofen difficult. Ten patients with serious burns were studied after the administration of 10 mg/kg ibuprofen suspension. The half-life varied from 1.4 to 5.1 hours, depending on the site of administration and/or the presence of solid food. The reported half-life for ibuprofen suspension is 1.8 to 2 hours. Burn size did not alter ibuprofen half-life or area under the time-concentration curve. Maximum ibuprofen concentration varied greatly, depending on route of administration. Time to maximal temperature reduction was between 2 and 3 hours after drug administration. Although the precise level of ibuprofen needed for cyclooxygenase inhibition is unknown, enterai administration results in levels below the targeted 10 to 20 mcg/ml for much of the traditional 6-hour dosing interval. Future studies with ibuprofen in the burn population must standardize more than just total dose.

Original languageEnglish (US)
Pages (from-to)666-669
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Volume14
Issue number6
DOIs
StatePublished - Jan 1 1993

Fingerprint

Ibuprofen
Pharmacokinetics
Wounds and Injuries
Half-Life
Suspensions
Antipyretics
Prostaglandin-Endoperoxide Synthases
Burns
Food
Temperature
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Surgery
  • Nursing(all)
  • Emergency Medicine
  • Rehabilitation
  • Health Professions(all)

Cite this

Cone, J. B., Wallace, B. H., Olsen, K. M., Caldwell, F. T., Gurley, B. J., & Bond, P. J. (1993). The pharmacokinetics of ibuprofen after burn injury. Journal of Burn Care and Rehabilitation, 14(6), 666-669. https://doi.org/10.1097/00004630-199311000-00012

The pharmacokinetics of ibuprofen after burn injury. / Cone, J. B.; Wallace, B. H.; Olsen, K. M.; Caldwell, F. T.; Gurley, B. J.; Bond, P. J.

In: Journal of Burn Care and Rehabilitation, Vol. 14, No. 6, 01.01.1993, p. 666-669.

Research output: Contribution to journalArticle

Cone, JB, Wallace, BH, Olsen, KM, Caldwell, FT, Gurley, BJ & Bond, PJ 1993, 'The pharmacokinetics of ibuprofen after burn injury', Journal of Burn Care and Rehabilitation, vol. 14, no. 6, pp. 666-669. https://doi.org/10.1097/00004630-199311000-00012
Cone JB, Wallace BH, Olsen KM, Caldwell FT, Gurley BJ, Bond PJ. The pharmacokinetics of ibuprofen after burn injury. Journal of Burn Care and Rehabilitation. 1993 Jan 1;14(6):666-669. https://doi.org/10.1097/00004630-199311000-00012
Cone, J. B. ; Wallace, B. H. ; Olsen, K. M. ; Caldwell, F. T. ; Gurley, B. J. ; Bond, P. J. / The pharmacokinetics of ibuprofen after burn injury. In: Journal of Burn Care and Rehabilitation. 1993 ; Vol. 14, No. 6. pp. 666-669.
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