The persistence of DNA damage in the pancreas of Syrian golden hamsters treated with N-nitrosobis(2-oxopropyl)amine

T. Lawson, L. Hines, S. Helgeson, P. Pour

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

DNA damage was estimated in the liver, pancreas and salivary gland of Syrian hamsters given N-nitrosobis(2-oxopropyl)amine (BOP) by alkaline sucrose gradient centrifugation. A single BOP dose (10 mg/kg) produced in all 3 tissues extensive DNA damage that was largely repaired in the salivary gland by 4 weeks, while in the liver and pancreas, some DNA damage persisted until 4 weeks. When higher BOP doses (20 and 40 mg/kg) were used, considerable DNA damage was still evident in the pancreas, but not in the liver at 6 weeks. Greater damage persisted in hamsters given 40 mg/kg, compared with those administered 20 mg/kg.

Original languageEnglish (US)
Pages (from-to)317-323
Number of pages7
JournalChemico-Biological Interactions
Volume38
Issue number3
DOIs
StatePublished - Feb 1982

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nitrosobis(2-oxopropyl)amine
Mesocricetus
DNA Damage
Pancreas
Liver
DNA
Salivary Glands
Centrifugation
Cricetinae
Sucrose
Tissue

ASJC Scopus subject areas

  • Toxicology

Cite this

The persistence of DNA damage in the pancreas of Syrian golden hamsters treated with N-nitrosobis(2-oxopropyl)amine. / Lawson, T.; Hines, L.; Helgeson, S.; Pour, P.

In: Chemico-Biological Interactions, Vol. 38, No. 3, 02.1982, p. 317-323.

Research output: Contribution to journalArticle

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