The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics

Maureen Lynch, Wun Ju Shieh, Kathleen Tatti, Jon R. Gentsch, Tara Ferebee-Harris, Baoming Jiang, Jeannette Guarner, Joesph S. Bresee, Margaret Greenwald, Steve Cullen, H. D. Davies, Cynthia Trevenen, Sherif R. Zaki, Roger I. Glass

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Rotavirus, the most common cause of severe, dehydrating gastroenteritis among children worldwide, annually causes ∼500,000 deaths among children aged <5 years. The primary site of rotavirus infection is the small intestine. Pathologic investigations of patients who died of rotavirus infection are limited to data from a few reported autopsies, and dehydration with electrolyte imbalance is believed to be the major cause of death. Several recent reports suggest that children who died during a rotavirus illness were viremic before death, because rotavirus was detected at several extraintestinal sites. We report 3 rotavirus-associated deaths among children, 2 of whom had evidence of rotavirus genome in extraintestinal tissues detected by use of novel molecular diagnostic methods. The part played by rotavirus in fatal cases is unclear and requires additional investigation of diarrhea-associated deaths, because a better understanding might alter the approach to treatment and the need for antiviral therapy.

Original languageEnglish (US)
Pages (from-to)1327-1333
Number of pages7
JournalClinical Infectious Diseases
Volume37
Issue number10
DOIs
StatePublished - Nov 15 2003

Fingerprint

Molecular Pathology
Rotavirus
Pathology
Rotavirus Infections
Gastroenteritis
Dehydration
Electrolytes
Small Intestine
Antiviral Agents
Cause of Death
Autopsy
Diarrhea
Genome
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Lynch, M., Shieh, W. J., Tatti, K., Gentsch, J. R., Ferebee-Harris, T., Jiang, B., ... Glass, R. I. (2003). The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics. Clinical Infectious Diseases, 37(10), 1327-1333. https://doi.org/10.1086/379322

The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics. / Lynch, Maureen; Shieh, Wun Ju; Tatti, Kathleen; Gentsch, Jon R.; Ferebee-Harris, Tara; Jiang, Baoming; Guarner, Jeannette; Bresee, Joesph S.; Greenwald, Margaret; Cullen, Steve; Davies, H. D.; Trevenen, Cynthia; Zaki, Sherif R.; Glass, Roger I.

In: Clinical Infectious Diseases, Vol. 37, No. 10, 15.11.2003, p. 1327-1333.

Research output: Contribution to journalArticle

Lynch, M, Shieh, WJ, Tatti, K, Gentsch, JR, Ferebee-Harris, T, Jiang, B, Guarner, J, Bresee, JS, Greenwald, M, Cullen, S, Davies, HD, Trevenen, C, Zaki, SR & Glass, RI 2003, 'The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics', Clinical Infectious Diseases, vol. 37, no. 10, pp. 1327-1333. https://doi.org/10.1086/379322
Lynch M, Shieh WJ, Tatti K, Gentsch JR, Ferebee-Harris T, Jiang B et al. The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics. Clinical Infectious Diseases. 2003 Nov 15;37(10):1327-1333. https://doi.org/10.1086/379322
Lynch, Maureen ; Shieh, Wun Ju ; Tatti, Kathleen ; Gentsch, Jon R. ; Ferebee-Harris, Tara ; Jiang, Baoming ; Guarner, Jeannette ; Bresee, Joesph S. ; Greenwald, Margaret ; Cullen, Steve ; Davies, H. D. ; Trevenen, Cynthia ; Zaki, Sherif R. ; Glass, Roger I. / The Pathology of Rotavirus-Associated Deaths, Using New Molecular Diagnostics. In: Clinical Infectious Diseases. 2003 ; Vol. 37, No. 10. pp. 1327-1333.
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