The pathogenesis of bladder cancer

G. H. Friedell, J. B. Jacobs, G. K. Nagy, Samuel Monroe Cohen

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Carcinoma of the urinary bladder appears to arise, in at least some cases, from carcinoma in situ developing in a field of atypical epithelial proliferaton. There is both a spatial and temporal relation between invasive and in situ bladder cancer, although the exact relation between the noninvasive flat and papillary types of tumors is not known. Preneoplastic bladder lesions are defined as irreversible, although not necessarily progressive, and an experimental animal model of the disease has been developed. The appearance of pleomorphic microvilli on the luminal surface of epithelial cells of the urinary bladders of Fischer rats is correlated with the irreversibility of hyperplastic epithelial lesions induced by feeding N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) to test animals. This alteration can be visualized by scanning electron microscopy of cytologic and histologic preparations.

Original languageEnglish (US)
Pages (from-to)431-442
Number of pages12
JournalAmerican Journal of Pathology
Volume89
Issue number2
StatePublished - Dec 1 1977

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Urinary Bladder Neoplasms
Urinary Bladder
FANFT
Animal Diseases
Carcinoma in Situ
Inbred F344 Rats
Microvilli
Electron Scanning Microscopy
Animal Models
Epithelial Cells
Carcinoma
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Friedell, G. H., Jacobs, J. B., Nagy, G. K., & Cohen, S. M. (1977). The pathogenesis of bladder cancer. American Journal of Pathology, 89(2), 431-442.

The pathogenesis of bladder cancer. / Friedell, G. H.; Jacobs, J. B.; Nagy, G. K.; Cohen, Samuel Monroe.

In: American Journal of Pathology, Vol. 89, No. 2, 01.12.1977, p. 431-442.

Research output: Contribution to journalArticle

Friedell, GH, Jacobs, JB, Nagy, GK & Cohen, SM 1977, 'The pathogenesis of bladder cancer', American Journal of Pathology, vol. 89, no. 2, pp. 431-442.
Friedell GH, Jacobs JB, Nagy GK, Cohen SM. The pathogenesis of bladder cancer. American Journal of Pathology. 1977 Dec 1;89(2):431-442.
Friedell, G. H. ; Jacobs, J. B. ; Nagy, G. K. ; Cohen, Samuel Monroe. / The pathogenesis of bladder cancer. In: American Journal of Pathology. 1977 ; Vol. 89, No. 2. pp. 431-442.
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