The origin of sympathetic outflow in heart failure

The roles of angiotensin II and nitric oxide

Irving H Zucker, Harold D Schultz, Yi Fan Li, Yu Wang, Wei Wang, Kaushik P Patel

Research output: Contribution to journalReview article

111 Citations (Scopus)

Abstract

The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.

Original languageEnglish (US)
Pages (from-to)217-232
Number of pages16
JournalProgress in Biophysics and Molecular Biology
Volume84
Issue number2-3
DOIs
StatePublished - Jan 1 2004

Fingerprint

Angiotensin II
Nitric Oxide
Heart Failure
Reflex
Genetic Techniques
Abnormal Reflexes
Baroreflex
Nitric Oxide Synthase
Brain

Keywords

  • Baroreflex
  • Chronic heart failure
  • Medulla
  • Neurohumoral regulation
  • Renal nerve activity

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology

Cite this

The origin of sympathetic outflow in heart failure : The roles of angiotensin II and nitric oxide. / Zucker, Irving H; Schultz, Harold D; Li, Yi Fan; Wang, Yu; Wang, Wei; Patel, Kaushik P.

In: Progress in Biophysics and Molecular Biology, Vol. 84, No. 2-3, 01.01.2004, p. 217-232.

Research output: Contribution to journalReview article

@article{b757cd5d26ef43bc94040dd7eb96e71d,
title = "The origin of sympathetic outflow in heart failure: The roles of angiotensin II and nitric oxide",
abstract = "The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.",
keywords = "Baroreflex, Chronic heart failure, Medulla, Neurohumoral regulation, Renal nerve activity",
author = "Zucker, {Irving H} and Schultz, {Harold D} and Li, {Yi Fan} and Yu Wang and Wei Wang and Patel, {Kaushik P}",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/j.pbiomolbio.2003.11.010",
language = "English (US)",
volume = "84",
pages = "217--232",
journal = "Progress in Biophysics and Molecular Biology",
issn = "0079-6107",
publisher = "Elsevier Limited",
number = "2-3",

}

TY - JOUR

T1 - The origin of sympathetic outflow in heart failure

T2 - The roles of angiotensin II and nitric oxide

AU - Zucker, Irving H

AU - Schultz, Harold D

AU - Li, Yi Fan

AU - Wang, Yu

AU - Wang, Wei

AU - Patel, Kaushik P

PY - 2004/1/1

Y1 - 2004/1/1

N2 - The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.

AB - The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.

KW - Baroreflex

KW - Chronic heart failure

KW - Medulla

KW - Neurohumoral regulation

KW - Renal nerve activity

UR - http://www.scopus.com/inward/record.url?scp=1242276575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242276575&partnerID=8YFLogxK

U2 - 10.1016/j.pbiomolbio.2003.11.010

DO - 10.1016/j.pbiomolbio.2003.11.010

M3 - Review article

VL - 84

SP - 217

EP - 232

JO - Progress in Biophysics and Molecular Biology

JF - Progress in Biophysics and Molecular Biology

SN - 0079-6107

IS - 2-3

ER -