The Open Source GAITOR Suite for Rodent Gait Analysis

Brittany Y. Jacobs, Emily H. Lakes, Alex J. Reiter, Spencer P. Lake, Trevor R. Ham, Nic D. Leipzig, Stacy L. Porvasnik, Christine E. Schmidt, Rebecca Wachs, Kyle D. Allen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Locomotive changes are often associated with disease or injury, and these changes can be quantified through gait analysis. Gait analysis has been applied to preclinical studies, providing quantitative behavioural assessment with a reasonable clinical analogue. However, available gait analysis technology for small animals is somewhat limited. Furthermore, technological and analytical challenges can limit the effectiveness of preclinical gait analysis. The Gait Analysis Instrumentation and Technology Optimized for Rodents (GAITOR) Suite is designed to increase the accessibility of preclinical gait analysis to researchers, facilitating hardware and software customization for broad applications. Here, the GAITOR Suite's utility is demonstrated in 4 models: a monoiodoacetate (MIA) injection model of joint pain, a sciatic nerve injury model, an elbow joint contracture model, and a spinal cord injury model. The GAITOR Suite identified unique compensatory gait patterns in each model, demonstrating the software's utility for detecting gait changes in rodent models of highly disparate injuries and diseases. Robust gait analysis may improve preclinical model selection, disease sequelae assessment, and evaluation of potential therapeutics. Our group has provided the GAITOR Suite as an open resource to the research community at www.GAITOR.org, aiming to promote and improve the implementation of gait analysis in preclinical rodent models.

Original languageEnglish (US)
Article number9797
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Gait
Rodentia
Technology
Wounds and Injuries
Software
Elbow Joint
Arthralgia
Contracture
Sciatic Nerve
Spinal Cord Injuries
Research Personnel

ASJC Scopus subject areas

  • General

Cite this

Jacobs, B. Y., Lakes, E. H., Reiter, A. J., Lake, S. P., Ham, T. R., Leipzig, N. D., ... Allen, K. D. (2018). The Open Source GAITOR Suite for Rodent Gait Analysis. Scientific reports, 8(1), [9797]. https://doi.org/10.1038/s41598-018-28134-1

The Open Source GAITOR Suite for Rodent Gait Analysis. / Jacobs, Brittany Y.; Lakes, Emily H.; Reiter, Alex J.; Lake, Spencer P.; Ham, Trevor R.; Leipzig, Nic D.; Porvasnik, Stacy L.; Schmidt, Christine E.; Wachs, Rebecca; Allen, Kyle D.

In: Scientific reports, Vol. 8, No. 1, 9797, 01.12.2018.

Research output: Contribution to journalArticle

Jacobs, BY, Lakes, EH, Reiter, AJ, Lake, SP, Ham, TR, Leipzig, ND, Porvasnik, SL, Schmidt, CE, Wachs, R & Allen, KD 2018, 'The Open Source GAITOR Suite for Rodent Gait Analysis', Scientific reports, vol. 8, no. 1, 9797. https://doi.org/10.1038/s41598-018-28134-1
Jacobs BY, Lakes EH, Reiter AJ, Lake SP, Ham TR, Leipzig ND et al. The Open Source GAITOR Suite for Rodent Gait Analysis. Scientific reports. 2018 Dec 1;8(1). 9797. https://doi.org/10.1038/s41598-018-28134-1
Jacobs, Brittany Y. ; Lakes, Emily H. ; Reiter, Alex J. ; Lake, Spencer P. ; Ham, Trevor R. ; Leipzig, Nic D. ; Porvasnik, Stacy L. ; Schmidt, Christine E. ; Wachs, Rebecca ; Allen, Kyle D. / The Open Source GAITOR Suite for Rodent Gait Analysis. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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