The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation

Timothy K. Eitas, Wei Chun Chou, Haitao Wen, Denis Gris, Gregory R. Robbins, June Brickey, Yoshitaka Oyama, Jenny P.Y. Ting

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: The nucleotide-binding leucine-rich repeat (NLR) family of innate immune genes are important regulators of inflammatory responses in mammals. Results: The NLR gene, Nlrx1, suppresses neuroinflammation in vivo and inhibits microglial (Mg) activation. Conclusion: NLRX1 immunosuppressive function in Mg correlates with suppression of neuroinflammation during mouse models of Multiple Sclerosis (MS). Significance: NLR genes can have protective roles during neuroinflammation.

Original languageEnglish (US)
Pages (from-to)4173-4179
Number of pages7
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
StatePublished - Feb 14 2014

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Autoimmune Experimental Encephalomyelitis
Macrophages
Microglia
Leucine
Nucleotides
Genes
Inflammation
Mammals
Regulator Genes
Immunosuppressive Agents
Multiple Sclerosis
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation. / Eitas, Timothy K.; Chou, Wei Chun; Wen, Haitao; Gris, Denis; Robbins, Gregory R.; Brickey, June; Oyama, Yoshitaka; Ting, Jenny P.Y.

In: Journal of Biological Chemistry, Vol. 289, No. 7, 14.02.2014, p. 4173-4179.

Research output: Contribution to journalArticle

Eitas, Timothy K. ; Chou, Wei Chun ; Wen, Haitao ; Gris, Denis ; Robbins, Gregory R. ; Brickey, June ; Oyama, Yoshitaka ; Ting, Jenny P.Y. / The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 7. pp. 4173-4179.
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