Abstract

This chapter reviews the epidemiology, clinical manifestations, and pathology of HIV-1-associated neurological disease and its associated encephalitis. Particular emphasis is placed on diagnosis, pathogenesis, and treatment options now available or under investigation. This chapter demonstrates how HIV-1 infection of the brain results in neuronal injury and death. Besides the significant morbidity induced by HIV-1 for cognitive, motor, and behavioral function, the CNS represents an important reservoir for continuous virus production and the emergence of viral strain variance. Moreover, the mechanisms of how mononuclear phagocytes (MP) secretory products may damage neurons have potential wide applicability for other neurodegenerative disorders where inflammation is an important component of disease pathogenesis. Adjunctive therapies such as N-methyl D-aspartate receptor (NMDAR) blockers, chemokine and cytokine effectors, antioxidants, caspase inhibitors, and p38MAPK inhibitors are all potential interventions and are being developed by many laboratories. If successful, these drugs may find utility in a broad range of neurodestructive processes.

Original languageEnglish (US)
Title of host publicationAIDS and Other Manifestations of HIV Infection
PublisherElsevier Inc.
Pages95-115
Number of pages21
ISBN (Electronic)9780080471969
ISBN (Print)9780127640518
DOIs
StatePublished - Apr 8 2004

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HIV Infections
HIV-1
Effector Caspases
Clinical Pathology
Caspase Inhibitors
Encephalitis
Phagocytes
N-Methyl-D-Aspartate Receptors
Chemokines
Neurodegenerative Diseases
Epidemiology
Antioxidants
Cytokines
Viruses
Inflammation
Morbidity
Neurons
Wounds and Injuries
Brain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gendelman, H. E., Diesing, S., Gelbard, H., & Swindells, S. (2004). The Neuropathogenesis of HIV-1 Infection. In AIDS and Other Manifestations of HIV Infection (pp. 95-115). Elsevier Inc.. https://doi.org/10.1016/B978-012764051-8/50007-X

The Neuropathogenesis of HIV-1 Infection. / Gendelman, Howard Eliot; Diesing, Scott; Gelbard, Harris; Swindells, Susan.

AIDS and Other Manifestations of HIV Infection. Elsevier Inc., 2004. p. 95-115.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gendelman, HE, Diesing, S, Gelbard, H & Swindells, S 2004, The Neuropathogenesis of HIV-1 Infection. in AIDS and Other Manifestations of HIV Infection. Elsevier Inc., pp. 95-115. https://doi.org/10.1016/B978-012764051-8/50007-X
Gendelman HE, Diesing S, Gelbard H, Swindells S. The Neuropathogenesis of HIV-1 Infection. In AIDS and Other Manifestations of HIV Infection. Elsevier Inc. 2004. p. 95-115 https://doi.org/10.1016/B978-012764051-8/50007-X
Gendelman, Howard Eliot ; Diesing, Scott ; Gelbard, Harris ; Swindells, Susan. / The Neuropathogenesis of HIV-1 Infection. AIDS and Other Manifestations of HIV Infection. Elsevier Inc., 2004. pp. 95-115
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