Abstract

HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage. Such activated and virus-infected macrophages secrete cellular and viral factors, triggering neural destructive immune responses. Our Center's laboratories have begun to decipher the molecular and biochemical pathways for MP-mediated neuronal damage in HAD. This review will discuss the salient clinical and pathological features of HAD and highlight the recent advances made, by our scientists and elsewhere, in unraveling disease mechanisms, including the role of chemokines and their receptors in the neuropathogenesis of HIV-1 encephalitis.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalFEMS Immunology and Medical Microbiology
Volume26
Issue number3-4
DOIs
StatePublished - Dec 1999

Fingerprint

Phagocytes
HIV Infections
HIV-1
Encephalitis
Macrophages
HIV
AIDS Dementia Complex
Chemokine Receptors
Microglia
Virus Diseases
Viruses
Brain

Keywords

  • CXCR4
  • HIV-1 associated cognitive/motor dysfunction (HAD)
  • HIV-1 encephalitis
  • Mononuclear phagocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

The neuropathogenesis of HIV-1 infection. / Zink, W. E.; Zheng, Jialin C; Persidsky, Y.; Poluektova, Larisa Y; Gendelman, Howard Eliot.

In: FEMS Immunology and Medical Microbiology, Vol. 26, No. 3-4, 12.1999, p. 233-241.

Research output: Contribution to journalArticle

@article{5bd32dbedcc44c83bdc3e290276832a6,
title = "The neuropathogenesis of HIV-1 infection",
abstract = "HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage. Such activated and virus-infected macrophages secrete cellular and viral factors, triggering neural destructive immune responses. Our Center's laboratories have begun to decipher the molecular and biochemical pathways for MP-mediated neuronal damage in HAD. This review will discuss the salient clinical and pathological features of HAD and highlight the recent advances made, by our scientists and elsewhere, in unraveling disease mechanisms, including the role of chemokines and their receptors in the neuropathogenesis of HIV-1 encephalitis.",
keywords = "CXCR4, HIV-1 associated cognitive/motor dysfunction (HAD), HIV-1 encephalitis, Mononuclear phagocyte",
author = "Zink, {W. E.} and Zheng, {Jialin C} and Y. Persidsky and Poluektova, {Larisa Y} and Gendelman, {Howard Eliot}",
year = "1999",
month = "12",
doi = "10.1016/S0928-8244(99)00152-2",
language = "English (US)",
volume = "26",
pages = "233--241",
journal = "Pathogens and Disease",
issn = "2049-632X",
publisher = "John Wiley & Sons Inc.",
number = "3-4",

}

TY - JOUR

T1 - The neuropathogenesis of HIV-1 infection

AU - Zink, W. E.

AU - Zheng, Jialin C

AU - Persidsky, Y.

AU - Poluektova, Larisa Y

AU - Gendelman, Howard Eliot

PY - 1999/12

Y1 - 1999/12

N2 - HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage. Such activated and virus-infected macrophages secrete cellular and viral factors, triggering neural destructive immune responses. Our Center's laboratories have begun to decipher the molecular and biochemical pathways for MP-mediated neuronal damage in HAD. This review will discuss the salient clinical and pathological features of HAD and highlight the recent advances made, by our scientists and elsewhere, in unraveling disease mechanisms, including the role of chemokines and their receptors in the neuropathogenesis of HIV-1 encephalitis.

AB - HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage. Such activated and virus-infected macrophages secrete cellular and viral factors, triggering neural destructive immune responses. Our Center's laboratories have begun to decipher the molecular and biochemical pathways for MP-mediated neuronal damage in HAD. This review will discuss the salient clinical and pathological features of HAD and highlight the recent advances made, by our scientists and elsewhere, in unraveling disease mechanisms, including the role of chemokines and their receptors in the neuropathogenesis of HIV-1 encephalitis.

KW - CXCR4

KW - HIV-1 associated cognitive/motor dysfunction (HAD)

KW - HIV-1 encephalitis

KW - Mononuclear phagocyte

UR - http://www.scopus.com/inward/record.url?scp=0033485688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033485688&partnerID=8YFLogxK

U2 - 10.1016/S0928-8244(99)00152-2

DO - 10.1016/S0928-8244(99)00152-2

M3 - Article

C2 - 10575134

AN - SCOPUS:0033485688

VL - 26

SP - 233

EP - 241

JO - Pathogens and Disease

JF - Pathogens and Disease

SN - 2049-632X

IS - 3-4

ER -