The natural history of group I introns

Peik Haugen, Dawn M. Simon, Debashish Bhattacharya

Research output: Contribution to journalReview article

228 Citations (Scopus)

Abstract

There are four major classes of introns: self-splicing group I and group II introns, tRNA and/or archaeal introns and spliceosomal introns in nuclear pre-mRNA. Group I introns are widely distributed in protists, bacteria and bacteriophages. Group II introns are found in fungal and land plant mitochondria, algal plastids, bacteria and Archaea. Group II and spliceosomal introns share a common splicing pathway and might be related to each other. The tRNA and/or archaeal introns are found in the nuclear tRNA of eukaryotes and in archaeal tRNA, rRNA and mRNA. The mechanisms underlying the self-splicing and mobility of a few model group I introns are well understood. By contrast, the role of these highly distinct processes in the evolution of the 1500 group I introns found thus far in nature (e.g. in algae and fungi) has only recently been clarified. The explosion of new sequence data has facilitated the use of comparative methods to understand group I intron evolution in a broader context and to generate hypotheses about intron insertion, splicing and spread that can be tested experimentally.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalTrends in Genetics
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2005

Fingerprint

Natural History
Introns
Transfer RNA
Embryophyta
Bacteria
Plastids
Explosions
Archaea
RNA Precursors
Eukaryota
Bacteriophages
Mitochondria
Fungi
Messenger RNA

ASJC Scopus subject areas

  • Genetics

Cite this

The natural history of group I introns. / Haugen, Peik; Simon, Dawn M.; Bhattacharya, Debashish.

In: Trends in Genetics, Vol. 21, No. 2, 01.02.2005, p. 111-119.

Research output: Contribution to journalReview article

Haugen, Peik ; Simon, Dawn M. ; Bhattacharya, Debashish. / The natural history of group I introns. In: Trends in Genetics. 2005 ; Vol. 21, No. 2. pp. 111-119.
@article{d629bcbb6cc244ea9758b5439c81797e,
title = "The natural history of group I introns",
abstract = "There are four major classes of introns: self-splicing group I and group II introns, tRNA and/or archaeal introns and spliceosomal introns in nuclear pre-mRNA. Group I introns are widely distributed in protists, bacteria and bacteriophages. Group II introns are found in fungal and land plant mitochondria, algal plastids, bacteria and Archaea. Group II and spliceosomal introns share a common splicing pathway and might be related to each other. The tRNA and/or archaeal introns are found in the nuclear tRNA of eukaryotes and in archaeal tRNA, rRNA and mRNA. The mechanisms underlying the self-splicing and mobility of a few model group I introns are well understood. By contrast, the role of these highly distinct processes in the evolution of the 1500 group I introns found thus far in nature (e.g. in algae and fungi) has only recently been clarified. The explosion of new sequence data has facilitated the use of comparative methods to understand group I intron evolution in a broader context and to generate hypotheses about intron insertion, splicing and spread that can be tested experimentally.",
author = "Peik Haugen and Simon, {Dawn M.} and Debashish Bhattacharya",
year = "2005",
month = "2",
day = "1",
doi = "10.1016/j.tig.2004.12.007",
language = "English (US)",
volume = "21",
pages = "111--119",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - The natural history of group I introns

AU - Haugen, Peik

AU - Simon, Dawn M.

AU - Bhattacharya, Debashish

PY - 2005/2/1

Y1 - 2005/2/1

N2 - There are four major classes of introns: self-splicing group I and group II introns, tRNA and/or archaeal introns and spliceosomal introns in nuclear pre-mRNA. Group I introns are widely distributed in protists, bacteria and bacteriophages. Group II introns are found in fungal and land plant mitochondria, algal plastids, bacteria and Archaea. Group II and spliceosomal introns share a common splicing pathway and might be related to each other. The tRNA and/or archaeal introns are found in the nuclear tRNA of eukaryotes and in archaeal tRNA, rRNA and mRNA. The mechanisms underlying the self-splicing and mobility of a few model group I introns are well understood. By contrast, the role of these highly distinct processes in the evolution of the 1500 group I introns found thus far in nature (e.g. in algae and fungi) has only recently been clarified. The explosion of new sequence data has facilitated the use of comparative methods to understand group I intron evolution in a broader context and to generate hypotheses about intron insertion, splicing and spread that can be tested experimentally.

AB - There are four major classes of introns: self-splicing group I and group II introns, tRNA and/or archaeal introns and spliceosomal introns in nuclear pre-mRNA. Group I introns are widely distributed in protists, bacteria and bacteriophages. Group II introns are found in fungal and land plant mitochondria, algal plastids, bacteria and Archaea. Group II and spliceosomal introns share a common splicing pathway and might be related to each other. The tRNA and/or archaeal introns are found in the nuclear tRNA of eukaryotes and in archaeal tRNA, rRNA and mRNA. The mechanisms underlying the self-splicing and mobility of a few model group I introns are well understood. By contrast, the role of these highly distinct processes in the evolution of the 1500 group I introns found thus far in nature (e.g. in algae and fungi) has only recently been clarified. The explosion of new sequence data has facilitated the use of comparative methods to understand group I intron evolution in a broader context and to generate hypotheses about intron insertion, splicing and spread that can be tested experimentally.

UR - http://www.scopus.com/inward/record.url?scp=12344329187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12344329187&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2004.12.007

DO - 10.1016/j.tig.2004.12.007

M3 - Review article

C2 - 15661357

AN - SCOPUS:12344329187

VL - 21

SP - 111

EP - 119

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 2

ER -