The mutation of V79 cells by N-nitrosobis(2-oxopropyl)amine activated by pancreas acinar and duct tissue from Syrian hamsters and MRC-Wistar rats

Terence Lawson, Carol Kolar, Donald Nagel

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The mutagenicity of N-nitrosobis(2-rmoxopropyl)amine was measured in the V79 assay using homogenates of acinar cells and duct tissue from the pancreases of Syrian hamsters and MRC-Wistar rats as the activating systems. Mutations at the sodium/potassium ATPase and hypoxanthine: guanine phosphoribosyltransferase loci were measured by resistance to ouabain and 6-thioguanine (TG). The order of effectiveness in generating mutagens from BOP was hamster duct, hamster acinar, rat duct, rat acinar. These data show extensive differences in BOP activation by hamster acinar and duct tissue.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalMutation Research/Genetic Toxicology
Volume240
Issue number4
DOIs
Publication statusPublished - Apr 1990

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Keywords

  • 6-Thioguanine resistance
  • N-Nitrosobis(2-oxopropyl)amine
  • Ouabain resistance
  • Pancreas acinar
  • V79 cells, mutation of

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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