The microbiology of human hygiene and its impact on type 1 diabetes

Nora M Chapman, Ken Coppieters, Matthias Von Herrath, Steven M Tracy

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The incidence of type 1 diabetes (T1D), as with several other autoimmune diseases and conditions, began to notably rise in the latter half of the last century. Most cases of T1D are not solely attributable to genetics and therefore, environmental influences are proposed to account for the difference. Humans live today in general under much more hygienic conditions than their ancestors. Although human enteroviruses (HEV) have been strongly implicated as causative environmental agents of T1D, recent work has shown that the bacterial genera in the gut of diabetics compared with non-diabetics, can vary significantly. Here, we consider these data in light of our non-hygienic human past in order to discuss a possible relationship between the resident bacterial biome and acute infectious events by HEV, suggesting how this may have influenced T1D incidences in the past and the risk for developing T1D today.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalIslets
Volume4
Issue number4
DOIs
StatePublished - Jan 1 2012

Fingerprint

Microbiology
Hygiene
Type 1 Diabetes Mellitus
Enterovirus
Incidence
Autoimmune Diseases
Ecosystem

Keywords

  • Autoimmunity
  • Bacteria
  • Enterovirus
  • Environment
  • Hygiene
  • Microbiology

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Chapman, N. M., Coppieters, K., Von Herrath, M., & Tracy, S. M. (2012). The microbiology of human hygiene and its impact on type 1 diabetes. Islets, 4(4), 253-261. https://doi.org/10.4161/isl.21570

The microbiology of human hygiene and its impact on type 1 diabetes. / Chapman, Nora M; Coppieters, Ken; Von Herrath, Matthias; Tracy, Steven M.

In: Islets, Vol. 4, No. 4, 01.01.2012, p. 253-261.

Research output: Contribution to journalReview article

Chapman, NM, Coppieters, K, Von Herrath, M & Tracy, SM 2012, 'The microbiology of human hygiene and its impact on type 1 diabetes', Islets, vol. 4, no. 4, pp. 253-261. https://doi.org/10.4161/isl.21570
Chapman NM, Coppieters K, Von Herrath M, Tracy SM. The microbiology of human hygiene and its impact on type 1 diabetes. Islets. 2012 Jan 1;4(4):253-261. https://doi.org/10.4161/isl.21570
Chapman, Nora M ; Coppieters, Ken ; Von Herrath, Matthias ; Tracy, Steven M. / The microbiology of human hygiene and its impact on type 1 diabetes. In: Islets. 2012 ; Vol. 4, No. 4. pp. 253-261.
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