The maximal size of protein to diffuse through the nuclear pore is larger than 60 kDa

Ruiwen Wang, Michael G. Brattain

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

It has generally been believed that the diffusion limit set by the nuclear pore for protein is 60 kDa. We here studied the cellular localization of several artificial proteins and found that the diffusion limit set by the nuclear pore is not as small as previously thought. The results indicate that the maximal size of protein to diffuse through the nuclear pore complex could be quite larger than 60 kDa, thus greatly extending the diffusion limit that the nuclear pore can accommodate.

Original languageEnglish (US)
Pages (from-to)3164-3170
Number of pages7
JournalFEBS Letters
Volume581
Issue number17
DOIs
Publication statusPublished - Jul 10 2007

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Keywords

  • Diffusion limit
  • Nuclear pore
  • Protein nuclear translocation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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