The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury

R. J. Gumina, P. J. Newman, D. Kenny, D. C. Warltier, G. J. Gross

Research output: Contribution to journalReview article

30 Scopus citations


Cell-cell and cell-matrix interactions are known to be mediated by specific cell adhesion receptors expressed on the cell surface. The characterization of these cell adhesion molecules has allowed researchers to examine their roles in a variety of physiologic and pathophysiologic conditions. Numerous studies have demonstrated that myocardial ischemia-reperfusion injury is an acute inflammatory process in which leukocytes are intimately involved. In this review we summarize the current data on the leukocyte cell adhesion cascade, focus upon studies which have demonstrated specific cell adhesion molecule interactions which mediate the leukocyte involvement in myocardial ischemia-reperfusion injury, and suggest future avenues of exploration and possible clinical implications of the studies reviewed.

Original languageEnglish (US)
Pages (from-to)201-213
Number of pages13
JournalBasic research in cardiology
Issue number4
Publication statusPublished - Aug 1 1997



  • Cell adhesion
  • Leukocytes
  • Myocardial ischemia-reperfusion injury

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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