The key events dose-response framework

A foundation for examining variability in elicitation thresholds for food allergens

Stephen L Taylor, Steven M. Gendel, Geert F. Houben, Elizabeth Julien

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Food allergies are caused by immunological reactions in individuals sensitized to normal protein components of foods. For any given sensitized individual, the severity of a reaction is generally assumed to be proportional to the dose of allergenic protein. There is substantial clinical evidence that threshold doses exist for the elicitation of an allergic reaction; however, the threshold (i.e., lowest dose that elicits a reaction) varies substantially across the sensitized population. Current approaches to protecting sensitized individuals from exposure to food allergens are highly qualitative (i.e., they rely on food avoidance). The Key Events Dose-Response Framework is an analytical approach for refining understanding of the biological basis of the dose-response. Application of this approach to food allergy provides a foundation for a more rigorous quantitative understanding of variability in allergic response. This study reviews the allergic disease process and the current approaches to identifying thresholds for food allergens. The pathway of key biological events occurring between food intake and allergic response is considered, along with factors that may determine the nature and severity of response to food allergens. Data needs, as well as implications for identifying thresholds, and for characterizing variability in thresholds, are also discussed.

Original languageEnglish (US)
Pages (from-to)729-739
Number of pages11
JournalCritical Reviews in Food Science and Nutrition
Volume49
Issue number8
DOIs
StatePublished - Sep 1 2009

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Allergens
allergens
dose response
food allergies
Food
dosage
Food Hypersensitivity
refining
Allergies
food choices
hypersensitivity
food intake
proteins
Proteins
Hypersensitivity
Eating
Refining
Population

Keywords

  • Food allergy
  • Key Events Dose-Response Framework
  • Low dose dose-response
  • Minimal eliciting dose
  • Thresholds

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

Cite this

The key events dose-response framework : A foundation for examining variability in elicitation thresholds for food allergens. / Taylor, Stephen L; Gendel, Steven M.; Houben, Geert F.; Julien, Elizabeth.

In: Critical Reviews in Food Science and Nutrition, Vol. 49, No. 8, 01.09.2009, p. 729-739.

Research output: Contribution to journalArticle

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