The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: Analysis of 126 patients from the International Peripheral T-cell Lymphoma Project

Jun Suzumiya, K. Ohshima, K. Tamura, K. Karube, N. Uike, K. Tobinai, R. D. Gascoyne, Julie Marie Vose, James Olen Armitage, D. D. Weisenburger

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Patients and methods: Among 1153 patients with T-cell or NK cell lymphomas, 126 patients (9.6%) with ATL were represented in this project. All were categorized as aggressive ATL, i.e. acute or lymphoma type, and 87% fell into the lymphoma type. Results: The median age was 62 years and the male to female ratio was 1.2 1. Significant prognostic factors for overall survival (OS) by univariate analysis were the presence of B symptoms (P = 0.018), platelet count <150 × 109/l (P = 0.065), and the International Prognostic Index (IPI; P = 0.019). However, multivariate analysis indicated that only the IPI was an independent predictor of OS. Combination chemotherapy including anthracyclines was given as the initial therapy in 109 of the 116 patients (94%) who received treatment, and the overall and complete response rates were 70% and 34%, respectively. However, there was no survival benefit for those receiving an anthracycline-containing regimen. Conclusion: Patients with aggressive ATL have a poor clinical outcome and the IPI is a useful model for predicting outcome in ATL of the lymphoma type.

Original languageEnglish (US)
Pages (from-to)715-721
Number of pages7
JournalAnnals of Oncology
Volume20
Issue number4
DOIs
StatePublished - Apr 7 2009

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Peripheral T-Cell Lymphoma
Adult T Cell Leukemia Lymphoma
Lymphoma
Anthracyclines
Natural Killer Cells
T-Lymphocytes
Survival
Survival Analysis
Combination Drug Therapy
Platelet Count
Therapeutics
Multivariate Analysis

Keywords

  • ATL
  • International
  • Leukemia
  • Lymphoma
  • Prognostic index
  • T-cell

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma : Analysis of 126 patients from the International Peripheral T-cell Lymphoma Project. / Suzumiya, Jun; Ohshima, K.; Tamura, K.; Karube, K.; Uike, N.; Tobinai, K.; Gascoyne, R. D.; Vose, Julie Marie; Armitage, James Olen; Weisenburger, D. D.

In: Annals of Oncology, Vol. 20, No. 4, 07.04.2009, p. 715-721.

Research output: Contribution to journalArticle

Suzumiya, Jun ; Ohshima, K. ; Tamura, K. ; Karube, K. ; Uike, N. ; Tobinai, K. ; Gascoyne, R. D. ; Vose, Julie Marie ; Armitage, James Olen ; Weisenburger, D. D. / The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma : Analysis of 126 patients from the International Peripheral T-cell Lymphoma Project. In: Annals of Oncology. 2009 ; Vol. 20, No. 4. pp. 715-721.
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AU - Tamura, K.

AU - Karube, K.

AU - Uike, N.

AU - Tobinai, K.

AU - Gascoyne, R. D.

AU - Vose, Julie Marie

AU - Armitage, James Olen

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