The integrated National NeuroAIDS Tissue Consortium database

a rich platform for neuroHIV research

Abigail J. Heithoff, Steven A. Totusek, Duc Le, Lucas Barwick, Gary Gensler, Donald R. Franklin, Allison C. Dye, Sanjit Pandey, Seth Sherman, Chittibabu Guda, Howard S Fox

Research output: Contribution to journalArticle

Abstract

Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.

Original languageEnglish (US)
JournalDatabase : the journal of biological databases and curation
Volume2019
DOIs
StatePublished - Jan 1 2019

Fingerprint

Databases
Tissue
Research
HIV
Neurology
central nervous system
Central Nervous System
Neuroimaging
tissues
therapeutics
immunosuppression
Pathology
Viruses
Ontology
researchers
Research Personnel
viruses
Testing
Therapeutics
testing

ASJC Scopus subject areas

  • Information Systems
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

The integrated National NeuroAIDS Tissue Consortium database : a rich platform for neuroHIV research. / Heithoff, Abigail J.; Totusek, Steven A.; Le, Duc; Barwick, Lucas; Gensler, Gary; Franklin, Donald R.; Dye, Allison C.; Pandey, Sanjit; Sherman, Seth; Guda, Chittibabu; Fox, Howard S.

In: Database : the journal of biological databases and curation, Vol. 2019, 01.01.2019.

Research output: Contribution to journalArticle

Heithoff, Abigail J. ; Totusek, Steven A. ; Le, Duc ; Barwick, Lucas ; Gensler, Gary ; Franklin, Donald R. ; Dye, Allison C. ; Pandey, Sanjit ; Sherman, Seth ; Guda, Chittibabu ; Fox, Howard S. / The integrated National NeuroAIDS Tissue Consortium database : a rich platform for neuroHIV research. In: Database : the journal of biological databases and curation. 2019 ; Vol. 2019.
@article{71332d74dae64e79a5021b7111da6c04,
title = "The integrated National NeuroAIDS Tissue Consortium database: a rich platform for neuroHIV research",
abstract = "Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.",
author = "Heithoff, {Abigail J.} and Totusek, {Steven A.} and Duc Le and Lucas Barwick and Gary Gensler and Franklin, {Donald R.} and Dye, {Allison C.} and Sanjit Pandey and Seth Sherman and Chittibabu Guda and Fox, {Howard S}",
year = "2019",
month = "1",
day = "1",
doi = "10.1093/database/bay134",
language = "English (US)",
volume = "2019",
journal = "Database : the journal of biological databases and curation",
issn = "1758-0463",
publisher = "Oxford University Press",

}

TY - JOUR

T1 - The integrated National NeuroAIDS Tissue Consortium database

T2 - a rich platform for neuroHIV research

AU - Heithoff, Abigail J.

AU - Totusek, Steven A.

AU - Le, Duc

AU - Barwick, Lucas

AU - Gensler, Gary

AU - Franklin, Donald R.

AU - Dye, Allison C.

AU - Pandey, Sanjit

AU - Sherman, Seth

AU - Guda, Chittibabu

AU - Fox, Howard S

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.

AB - Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.

UR - http://www.scopus.com/inward/record.url?scp=85059797010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059797010&partnerID=8YFLogxK

U2 - 10.1093/database/bay134

DO - 10.1093/database/bay134

M3 - Article

VL - 2019

JO - Database : the journal of biological databases and curation

JF - Database : the journal of biological databases and curation

SN - 1758-0463

ER -