The insulin-like growth factor binding protein superfamily

New perspectives

Ron G. Rosenfeld, Vivian Hwa, Lisa Wilson, Abel Lopez-Bermejo, Caroline Buckway, Christine Burren, Won Kyu Choi, Gayathri Devi, Angela Ingermann, Donna Graham, Giuseppi Minniti, Anna Spagnoli, Youngman Oh

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The insulin-like growth factor (IGF) binding proteins (IGFBPs) were initially identified as carrier proteins for IGF-I and IGF-II in a variety of biologic fluids. Their presumed function was to protect IGF peptides from degradation and clearance, increase the half-life of the IGFs, and deliver them to appropriate tissue receptors. The concept of IGFBPs as simple carrier proteins has been complicated, however, by a number of observations: 1) the six IGFBPs vary in their tissue expression and their regulation by other hormones and growth factors; 2) the IGFBPs are subjected to proteolytic degradation, thereby altering their affinities for the IGFs; 3) IGFBP-3 and IGFBP-5, in addition to binding IGFs, also can associate with an acid-labile subunit, thereby increasing further the half-life of the IGFs; 4) in addition to modifying the access of IGF peptides to IGF and insulin receptors, several of the IGFBPs may be capable of increasing IGF action; 5) some of the IGFBPs may be capable of IGF-independent regulation of cell growth; 6) some of the IGFBPs are associated with cell membranes or possibly with membrane receptors; and 7) some of the IGFBPs have nuclear recognition sites and may be found within the nucleus. Additionally, a number of cDNAs identified recently have been found to encode proteins that bind IGFs, but with substantially lower affinities than is the case with IGFBPs. The N-terminal regions of the predicted proteins are structurally homologous to the classic IGFBPs, with conservation of the cysteine-rich region. These observations suggest that these low-affinity binders are members of an IGFBP superfamily, capable of regulating cell growth by both IGF-dependent and IGF-independent mechanisms.

Original languageEnglish (US)
Pages (from-to)1018-1020
Number of pages3
JournalPediatrics
Volume104
Issue number4 II
StatePublished - Oct 1 1999

Fingerprint

Insulin-Like Growth Factor Binding Proteins
Somatomedins
Insulin-Like Growth Factor Binding Protein 5
Half-Life
Carrier Proteins
Insulin-Like Growth Factor Binding Protein 6
Insulin-Like Growth Factor Binding Protein 2
Somatomedin Receptors
Insulin-Like Growth Factor Binding Protein 1
Peptides
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor II
Insulin Receptor
Growth
Insulin-Like Growth Factor I
Cysteine
Intercellular Signaling Peptides and Proteins
Proteins
Complementary DNA
Cell Membrane

Keywords

  • Insulin-like growth factor
  • Insulin-like growth factor binding proteins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Rosenfeld, R. G., Hwa, V., Wilson, L., Lopez-Bermejo, A., Buckway, C., Burren, C., ... Oh, Y. (1999). The insulin-like growth factor binding protein superfamily: New perspectives. Pediatrics, 104(4 II), 1018-1020.

The insulin-like growth factor binding protein superfamily : New perspectives. / Rosenfeld, Ron G.; Hwa, Vivian; Wilson, Lisa; Lopez-Bermejo, Abel; Buckway, Caroline; Burren, Christine; Choi, Won Kyu; Devi, Gayathri; Ingermann, Angela; Graham, Donna; Minniti, Giuseppi; Spagnoli, Anna; Oh, Youngman.

In: Pediatrics, Vol. 104, No. 4 II, 01.10.1999, p. 1018-1020.

Research output: Contribution to journalArticle

Rosenfeld, RG, Hwa, V, Wilson, L, Lopez-Bermejo, A, Buckway, C, Burren, C, Choi, WK, Devi, G, Ingermann, A, Graham, D, Minniti, G, Spagnoli, A & Oh, Y 1999, 'The insulin-like growth factor binding protein superfamily: New perspectives', Pediatrics, vol. 104, no. 4 II, pp. 1018-1020.
Rosenfeld RG, Hwa V, Wilson L, Lopez-Bermejo A, Buckway C, Burren C et al. The insulin-like growth factor binding protein superfamily: New perspectives. Pediatrics. 1999 Oct 1;104(4 II):1018-1020.
Rosenfeld, Ron G. ; Hwa, Vivian ; Wilson, Lisa ; Lopez-Bermejo, Abel ; Buckway, Caroline ; Burren, Christine ; Choi, Won Kyu ; Devi, Gayathri ; Ingermann, Angela ; Graham, Donna ; Minniti, Giuseppi ; Spagnoli, Anna ; Oh, Youngman. / The insulin-like growth factor binding protein superfamily : New perspectives. In: Pediatrics. 1999 ; Vol. 104, No. 4 II. pp. 1018-1020.
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