The influence of antipyrene on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced urinary tract carcinogenesis

Sonny L. Johansson, Claes Anderström

Research output: Contribution to journalArticle

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Abstract

Human over-use of analgesics containing phenacetin, antipyrene (phenazone) and caffeine has been associated with the development of both renal pelvic and bladder tumors. In Sprague-Dawley rats antipyrene has been shown to be a weak complete urinary tract carcinogen. The present study was designed to evaluate the promoting capacity of antipyrene in N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT)-induced urinary tract carcinogenesis. One hundred and eighty male Sprague-Dawley rats were divided into groups of 30 and were treated with the following chemicals in the diet: group 1 received a control diet without chemicals; group 2 was treated with 0.2% FANFT in the diet for five weeks followed by control diet; group 3 received 0.2% FANFT for five weeks followed by 0.535% antipyrene in the diet; group 4 was treated with 0.535% antipyrene; group 5 was treated with 0.102% caffeine; and group 6 was treated with 0.535% antipyrene and 0.102% caffeine in the diet. Ten of 27 rats in group 3(37%) developed urinary tract tumors (P> 0.001, five of which were renal pelvic tumors and five were bladder tumors. The majority of the tumors were well differentiated non-invasive urothelial carcinomas. None of the rats in other groups developed urinary tract tumors. In addition, renal papillary necrosis (RPN) was found in 33% of the rats in group 3, 50% in group 4, and 10% in group 6. The present study clearly shows that antipyrene acts as a promoter of FANFT-induced urinary tract carcinogenesis and that it is nephrotoxic to the renal papilla resulting in renal papillary necrosis.

Original languageEnglish (US)
Pages (from-to)783-787
Number of pages5
JournalCarcinogenesis
Volume9
Issue number5
DOIs
StatePublished - May 1 1988

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FANFT
Urinary Tract
Carcinogenesis
Diet
Kidney
Caffeine
Urinary Bladder Neoplasms
Sprague Dawley Rats
Neoplasms
Necrosis
Phenacetin
Antipyrine
Carcinogens
Analgesics
formamide
Carcinoma

ASJC Scopus subject areas

  • Cancer Research

Cite this

The influence of antipyrene on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced urinary tract carcinogenesis. / Johansson, Sonny L.; Anderström, Claes.

In: Carcinogenesis, Vol. 9, No. 5, 01.05.1988, p. 783-787.

Research output: Contribution to journalArticle

Johansson, Sonny L. ; Anderström, Claes. / The influence of antipyrene on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced urinary tract carcinogenesis. In: Carcinogenesis. 1988 ; Vol. 9, No. 5. pp. 783-787.
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abstract = "Human over-use of analgesics containing phenacetin, antipyrene (phenazone) and caffeine has been associated with the development of both renal pelvic and bladder tumors. In Sprague-Dawley rats antipyrene has been shown to be a weak complete urinary tract carcinogen. The present study was designed to evaluate the promoting capacity of antipyrene in N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT)-induced urinary tract carcinogenesis. One hundred and eighty male Sprague-Dawley rats were divided into groups of 30 and were treated with the following chemicals in the diet: group 1 received a control diet without chemicals; group 2 was treated with 0.2{\%} FANFT in the diet for five weeks followed by control diet; group 3 received 0.2{\%} FANFT for five weeks followed by 0.535{\%} antipyrene in the diet; group 4 was treated with 0.535{\%} antipyrene; group 5 was treated with 0.102{\%} caffeine; and group 6 was treated with 0.535{\%} antipyrene and 0.102{\%} caffeine in the diet. Ten of 27 rats in group 3(37{\%}) developed urinary tract tumors (P> 0.001, five of which were renal pelvic tumors and five were bladder tumors. The majority of the tumors were well differentiated non-invasive urothelial carcinomas. None of the rats in other groups developed urinary tract tumors. In addition, renal papillary necrosis (RPN) was found in 33{\%} of the rats in group 3, 50{\%} in group 4, and 10{\%} in group 6. The present study clearly shows that antipyrene acts as a promoter of FANFT-induced urinary tract carcinogenesis and that it is nephrotoxic to the renal papilla resulting in renal papillary necrosis.",
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