The Inflammasome NLRs in immunity, inflammation, and associated diseases

Beckley K. Davis, Haitao Wen, Jenny P.Y. Ting

Research output: Contribution to journalArticle

828 Scopus citations

Abstract

Inflammasome activation leads to caspase-1 activation, which causes the maturation and secretion of pro-IL-1βand pro-IL-18 among other substrates. A subgroup of the NLR (nucleotide-binding domain, leucine-rich repeat containing) proteins are key mediators of the inflammasome. Studies of gene-deficient mice and cells have implicated NLR inflammasomes in a host of responses to a wide range of microbial pathogens, inflammatory diseases, cancer, and metabolic and autoimmune disorders. Determining exactly how the inflammasome is activated in these diseases and disease models remains a challenge. This review presents and integrates recent progress in the field.

Original languageEnglish (US)
Pages (from-to)707-735
Number of pages29
JournalAnnual Review of Immunology
Volume29
DOIs
StatePublished - Apr 23 2011

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Keywords

  • IL-1β
  • cancer
  • caspase-1
  • innate immunity
  • metabolic diseases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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