The incidence of spondylolysis and spondylolisthesis in children with osteogenesis imperfecta

Daniel Hatz, Paul William Esposito, Bruce Schroeder, Bridget Burke, Richard E Lutz, Brian P Hasley

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Background: Spondylolysis and spondylolisthesis are common abnormalities of the lumbar spine. The incidence of these diagnoses is recognized in the healthy population. However, their incidence in osteogenesis imperfecta (OI) patients is less well defined. Methods: This is a retrospective radiographic review of patients treated in the OI clinic from a single institution. Lateral radiographs were reviewed on all available patients to assess the incidence of spondylolysis and spondylolisthesis in this patient population. The morphology of the pedicle and pars interarticularis was also evaluated to identify any abnormalities or dysplasia of these structures. Results: One hundred ten of the 139 patients treated in the OI clinic met the inclusion criteria for this study. Of these patients, 79% (87 of 110) were ambulatory. The overall incidence of spondylolysis in this pediatric OI population was found to be 8.2% (9 of 110) at an average age of 7.5 years. The incidence of spondylolisthesis was 10.9% (12 of 110) at an average age of 6.5 years with 75% (3 of 12) being isthmic type and 25% (3 of 12) dysplastic. The combined incidence of spondylolysis and spondylolisthesis was 19.2%. Incidentally, the pedicle length was noted to be elongated in 40.0% (44 of 110) of this OI population. Conclusions: This study found that the incidence of spondylolysis in a group of children with OI was much higher than in the normal pediatric population, which has been reported to be 2.6% to 4.0%. This incidence was also found to be higher than previously reported incidence of spondylolysis in OI patients (5.3%). The incidence of spondylolisthesis was also found to be much higher than that of the normal pediatric population (4.2%). It is important to recognize this higher incidence of these abnormalities and to anticipate future associated symptoms and potential worsening listhesis that can clinically affect the lifestyles of these children and potentially require surgical treatment. The clinical significance of these findings will necessitate long-term follow-up.

Original languageEnglish (US)
Pages (from-to)655-660
Number of pages6
JournalJournal of Pediatric Orthopaedics
Volume31
Issue number6
DOIs
StatePublished - Sep 1 2011

Fingerprint

Spondylolysis
Spondylolisthesis
Osteogenesis Imperfecta
Incidence
Population
Pediatrics
Life Style
Spine
Cohort Studies

Keywords

  • osteogenesis imperfecta
  • spondylolisthesis
  • spondylolysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Orthopedics and Sports Medicine

Cite this

The incidence of spondylolysis and spondylolisthesis in children with osteogenesis imperfecta. / Hatz, Daniel; Esposito, Paul William; Schroeder, Bruce; Burke, Bridget; Lutz, Richard E; Hasley, Brian P.

In: Journal of Pediatric Orthopaedics, Vol. 31, No. 6, 01.09.2011, p. 655-660.

Research output: Contribution to journalReview article

@article{e00e12a1645d44e4baa7bdeddaad5a14,
title = "The incidence of spondylolysis and spondylolisthesis in children with osteogenesis imperfecta",
abstract = "Background: Spondylolysis and spondylolisthesis are common abnormalities of the lumbar spine. The incidence of these diagnoses is recognized in the healthy population. However, their incidence in osteogenesis imperfecta (OI) patients is less well defined. Methods: This is a retrospective radiographic review of patients treated in the OI clinic from a single institution. Lateral radiographs were reviewed on all available patients to assess the incidence of spondylolysis and spondylolisthesis in this patient population. The morphology of the pedicle and pars interarticularis was also evaluated to identify any abnormalities or dysplasia of these structures. Results: One hundred ten of the 139 patients treated in the OI clinic met the inclusion criteria for this study. Of these patients, 79{\%} (87 of 110) were ambulatory. The overall incidence of spondylolysis in this pediatric OI population was found to be 8.2{\%} (9 of 110) at an average age of 7.5 years. The incidence of spondylolisthesis was 10.9{\%} (12 of 110) at an average age of 6.5 years with 75{\%} (3 of 12) being isthmic type and 25{\%} (3 of 12) dysplastic. The combined incidence of spondylolysis and spondylolisthesis was 19.2{\%}. Incidentally, the pedicle length was noted to be elongated in 40.0{\%} (44 of 110) of this OI population. Conclusions: This study found that the incidence of spondylolysis in a group of children with OI was much higher than in the normal pediatric population, which has been reported to be 2.6{\%} to 4.0{\%}. This incidence was also found to be higher than previously reported incidence of spondylolysis in OI patients (5.3{\%}). The incidence of spondylolisthesis was also found to be much higher than that of the normal pediatric population (4.2{\%}). It is important to recognize this higher incidence of these abnormalities and to anticipate future associated symptoms and potential worsening listhesis that can clinically affect the lifestyles of these children and potentially require surgical treatment. The clinical significance of these findings will necessitate long-term follow-up.",
keywords = "osteogenesis imperfecta, spondylolisthesis, spondylolysis",
author = "Daniel Hatz and Esposito, {Paul William} and Bruce Schroeder and Bridget Burke and Lutz, {Richard E} and Hasley, {Brian P}",
year = "2011",
month = "9",
day = "1",
doi = "10.1097/BPO.0b013e31822889c9",
language = "English (US)",
volume = "31",
pages = "655--660",
journal = "Journal of Pediatric Orthopaedics",
issn = "0271-6798",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - The incidence of spondylolysis and spondylolisthesis in children with osteogenesis imperfecta

AU - Hatz, Daniel

AU - Esposito, Paul William

AU - Schroeder, Bruce

AU - Burke, Bridget

AU - Lutz, Richard E

AU - Hasley, Brian P

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Background: Spondylolysis and spondylolisthesis are common abnormalities of the lumbar spine. The incidence of these diagnoses is recognized in the healthy population. However, their incidence in osteogenesis imperfecta (OI) patients is less well defined. Methods: This is a retrospective radiographic review of patients treated in the OI clinic from a single institution. Lateral radiographs were reviewed on all available patients to assess the incidence of spondylolysis and spondylolisthesis in this patient population. The morphology of the pedicle and pars interarticularis was also evaluated to identify any abnormalities or dysplasia of these structures. Results: One hundred ten of the 139 patients treated in the OI clinic met the inclusion criteria for this study. Of these patients, 79% (87 of 110) were ambulatory. The overall incidence of spondylolysis in this pediatric OI population was found to be 8.2% (9 of 110) at an average age of 7.5 years. The incidence of spondylolisthesis was 10.9% (12 of 110) at an average age of 6.5 years with 75% (3 of 12) being isthmic type and 25% (3 of 12) dysplastic. The combined incidence of spondylolysis and spondylolisthesis was 19.2%. Incidentally, the pedicle length was noted to be elongated in 40.0% (44 of 110) of this OI population. Conclusions: This study found that the incidence of spondylolysis in a group of children with OI was much higher than in the normal pediatric population, which has been reported to be 2.6% to 4.0%. This incidence was also found to be higher than previously reported incidence of spondylolysis in OI patients (5.3%). The incidence of spondylolisthesis was also found to be much higher than that of the normal pediatric population (4.2%). It is important to recognize this higher incidence of these abnormalities and to anticipate future associated symptoms and potential worsening listhesis that can clinically affect the lifestyles of these children and potentially require surgical treatment. The clinical significance of these findings will necessitate long-term follow-up.

AB - Background: Spondylolysis and spondylolisthesis are common abnormalities of the lumbar spine. The incidence of these diagnoses is recognized in the healthy population. However, their incidence in osteogenesis imperfecta (OI) patients is less well defined. Methods: This is a retrospective radiographic review of patients treated in the OI clinic from a single institution. Lateral radiographs were reviewed on all available patients to assess the incidence of spondylolysis and spondylolisthesis in this patient population. The morphology of the pedicle and pars interarticularis was also evaluated to identify any abnormalities or dysplasia of these structures. Results: One hundred ten of the 139 patients treated in the OI clinic met the inclusion criteria for this study. Of these patients, 79% (87 of 110) were ambulatory. The overall incidence of spondylolysis in this pediatric OI population was found to be 8.2% (9 of 110) at an average age of 7.5 years. The incidence of spondylolisthesis was 10.9% (12 of 110) at an average age of 6.5 years with 75% (3 of 12) being isthmic type and 25% (3 of 12) dysplastic. The combined incidence of spondylolysis and spondylolisthesis was 19.2%. Incidentally, the pedicle length was noted to be elongated in 40.0% (44 of 110) of this OI population. Conclusions: This study found that the incidence of spondylolysis in a group of children with OI was much higher than in the normal pediatric population, which has been reported to be 2.6% to 4.0%. This incidence was also found to be higher than previously reported incidence of spondylolysis in OI patients (5.3%). The incidence of spondylolisthesis was also found to be much higher than that of the normal pediatric population (4.2%). It is important to recognize this higher incidence of these abnormalities and to anticipate future associated symptoms and potential worsening listhesis that can clinically affect the lifestyles of these children and potentially require surgical treatment. The clinical significance of these findings will necessitate long-term follow-up.

KW - osteogenesis imperfecta

KW - spondylolisthesis

KW - spondylolysis

UR - http://www.scopus.com/inward/record.url?scp=80051997902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051997902&partnerID=8YFLogxK

U2 - 10.1097/BPO.0b013e31822889c9

DO - 10.1097/BPO.0b013e31822889c9

M3 - Review article

C2 - 21841441

AN - SCOPUS:80051997902

VL - 31

SP - 655

EP - 660

JO - Journal of Pediatric Orthopaedics

JF - Journal of Pediatric Orthopaedics

SN - 0271-6798

IS - 6

ER -