The impact of hypoxic-ischemic brain injury on stem cell mobilization, migration, adhesion, and proliferation

Stephanie Parry, Eric S Peeples

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Neonatal hypoxic-ischemic encephalopathy continues to be a significant cause of death or neurodevelopmental delays despite standard use of therapeutic hypothermia. The use of stem cell transplantation has recently emerged as a promising supplemental therapy to further improve the outcomes of infants with hypoxic-ischemic encephalopathy. After the injury, the brain releases several chemical mediators, many of which communicate directly with stem cells to encourage mobilization, migration, cell adhesion and differentiation. This manuscript reviews the biomarkers that are released from the injured brain and their interactions with stem cells, providing insight regarding how their upregulation could improve stem cell therapy by maximizing cell delivery to the injured tissue.

Original languageEnglish (US)
Pages (from-to)1125-1135
Number of pages11
JournalNeural Regeneration Research
Volume13
Issue number7
DOIs
StatePublished - Jul 1 2018

Fingerprint

Hematopoietic Stem Cell Mobilization
Brain Injuries
Cell Movement
Brain Hypoxia-Ischemia
Stem Cells
Induced Hypothermia
Stem Cell Transplantation
Cell- and Tissue-Based Therapy
Cell Adhesion
Cell Differentiation
Cause of Death
Up-Regulation
Biomarkers
Brain
Therapeutics

Keywords

  • Brain-Derived neurotrophic
  • Erythropoietin
  • Factor
  • Hypoxia inducible
  • Matrix metalloproteinase
  • Neonatal
  • Stromal cell-derived
  • Vascular endothelial growth

ASJC Scopus subject areas

  • Developmental Neuroscience

Cite this

The impact of hypoxic-ischemic brain injury on stem cell mobilization, migration, adhesion, and proliferation. / Parry, Stephanie; Peeples, Eric S.

In: Neural Regeneration Research, Vol. 13, No. 7, 01.07.2018, p. 1125-1135.

Research output: Contribution to journalReview article

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