The immunophenotype of T-lymphoblastic lymphoma in children and adolescents

A children's oncology group report

Jay L. Patel, Lynette M Smith, James Anderson, Minnie Abromowitch, Dario Campana, Jeffrey Jacobsen, Mark A. Lones, Thomas G. Gross, Mitchell S. Cairo, Sherrie L. Perkins

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

T-lymphoblastic leukaemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms derived from immature lymphoid cells of T-cell lineage. These neoplasms are biologically similar, but significant differences may exist between the two given their clinical differences. Although ample data regarding the immunophenotypic characterization T-ALL are available, there is a paucity of such data in children and adolescents with T-LBL. We used flow cytometry and/or immunohistochemistry to characterize the immunophenotypic profile of 180 children and adolescents with newly diagnosed T-LBL enrolled in the Children's Oncology Group 5971 study. Multiple T-cell, B-cell, myeloid, and other markers were evaluated. We identified diagnostically useful immunophenotypic features of T-LBL as well as distinct immunophenotypic subgroups, although none of these was statistically related to event-free or overall survival in this retrospective analysis. Further studies of biologically and immunophenotypically distinct subgroups of T-LBL, such as the early T-cell precursor phenotype, are warranted.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
JournalBritish Journal of Haematology
Volume159
Issue number4
DOIs
StatePublished - Nov 1 2012

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphoid Precursor Cells
T-Lymphocytes
Cell Lineage
Neoplasms
Flow Cytometry
B-Lymphocytes
Immunohistochemistry
Lymphocytes
Phenotype

Keywords

  • Early T-cell precursor
  • Immunophenotypic analysis
  • Paediatric lymphoma
  • T-cell antigens
  • T-lymphoblastic lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

The immunophenotype of T-lymphoblastic lymphoma in children and adolescents : A children's oncology group report. / Patel, Jay L.; Smith, Lynette M; Anderson, James; Abromowitch, Minnie; Campana, Dario; Jacobsen, Jeffrey; Lones, Mark A.; Gross, Thomas G.; Cairo, Mitchell S.; Perkins, Sherrie L.

In: British Journal of Haematology, Vol. 159, No. 4, 01.11.2012, p. 454-461.

Research output: Contribution to journalArticle

Patel, JL, Smith, LM, Anderson, J, Abromowitch, M, Campana, D, Jacobsen, J, Lones, MA, Gross, TG, Cairo, MS & Perkins, SL 2012, 'The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report', British Journal of Haematology, vol. 159, no. 4, pp. 454-461. https://doi.org/10.1111/bjh.12042
Patel, Jay L. ; Smith, Lynette M ; Anderson, James ; Abromowitch, Minnie ; Campana, Dario ; Jacobsen, Jeffrey ; Lones, Mark A. ; Gross, Thomas G. ; Cairo, Mitchell S. ; Perkins, Sherrie L. / The immunophenotype of T-lymphoblastic lymphoma in children and adolescents : A children's oncology group report. In: British Journal of Haematology. 2012 ; Vol. 159, No. 4. pp. 454-461.
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