The immune response in the pathogenesis of alcoholic liver disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many hypotheses have been put forward to explain ethanolinduced liver damage, including direct and indirect toxicity. Despite many years of intensive research, the molecular mechanisms involved in the toxicity of this simple compound have still not been fully clarified. Initial studies investigated the direct toxic effects of ethanol on tissues, but it is now believed that the products of ethanol metabolism are the major factors causing alcoholic liver disease (ALD). The metabolic products and metabolic events induced by alcohol ingestion are varied in nature and vast in scope. Major research interest has focused on the effects of aldehyde production, oxygen radical formation, mitochondrial membrane permeability defects, endotoxins, and infectious agents as factors in hepatocellular dysfunction and cell death. At the same time, increasing evidence suggests that immune-mediated mechanisms are involved in ALD.

Original languageEnglish (US)
Title of host publicationLiver Immunology
Subtitle of host publicationPrinciples and Practice
PublisherHumana Press
Pages309-321
Number of pages13
ISBN (Print)9781588298188
DOIs
StatePublished - Dec 1 2007

Fingerprint

Alcoholic Liver Diseases
Ethanol
Poisons
Mitochondrial Membranes
Research
Aldehydes
Endotoxins
Permeability
Reactive Oxygen Species
Cell Death
Eating
Alcohols
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The immune response in the pathogenesis of alcoholic liver disease. / Klassen, Lynell Warren; Thiele, Geoffrey Milton.

Liver Immunology: Principles and Practice. Humana Press, 2007. p. 309-321.

Research output: Chapter in Book/Report/Conference proceedingChapter

Klassen, Lynell Warren ; Thiele, Geoffrey Milton. / The immune response in the pathogenesis of alcoholic liver disease. Liver Immunology: Principles and Practice. Humana Press, 2007. pp. 309-321
@inbook{c082f3e101504c33b57892342bcec274,
title = "The immune response in the pathogenesis of alcoholic liver disease",
abstract = "Many hypotheses have been put forward to explain ethanolinduced liver damage, including direct and indirect toxicity. Despite many years of intensive research, the molecular mechanisms involved in the toxicity of this simple compound have still not been fully clarified. Initial studies investigated the direct toxic effects of ethanol on tissues, but it is now believed that the products of ethanol metabolism are the major factors causing alcoholic liver disease (ALD). The metabolic products and metabolic events induced by alcohol ingestion are varied in nature and vast in scope. Major research interest has focused on the effects of aldehyde production, oxygen radical formation, mitochondrial membrane permeability defects, endotoxins, and infectious agents as factors in hepatocellular dysfunction and cell death. At the same time, increasing evidence suggests that immune-mediated mechanisms are involved in ALD.",
author = "Klassen, {Lynell Warren} and Thiele, {Geoffrey Milton}",
year = "2007",
month = "12",
day = "1",
doi = "10.1007/978-1-59745-518-3_25",
language = "English (US)",
isbn = "9781588298188",
pages = "309--321",
booktitle = "Liver Immunology",
publisher = "Humana Press",

}

TY - CHAP

T1 - The immune response in the pathogenesis of alcoholic liver disease

AU - Klassen, Lynell Warren

AU - Thiele, Geoffrey Milton

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Many hypotheses have been put forward to explain ethanolinduced liver damage, including direct and indirect toxicity. Despite many years of intensive research, the molecular mechanisms involved in the toxicity of this simple compound have still not been fully clarified. Initial studies investigated the direct toxic effects of ethanol on tissues, but it is now believed that the products of ethanol metabolism are the major factors causing alcoholic liver disease (ALD). The metabolic products and metabolic events induced by alcohol ingestion are varied in nature and vast in scope. Major research interest has focused on the effects of aldehyde production, oxygen radical formation, mitochondrial membrane permeability defects, endotoxins, and infectious agents as factors in hepatocellular dysfunction and cell death. At the same time, increasing evidence suggests that immune-mediated mechanisms are involved in ALD.

AB - Many hypotheses have been put forward to explain ethanolinduced liver damage, including direct and indirect toxicity. Despite many years of intensive research, the molecular mechanisms involved in the toxicity of this simple compound have still not been fully clarified. Initial studies investigated the direct toxic effects of ethanol on tissues, but it is now believed that the products of ethanol metabolism are the major factors causing alcoholic liver disease (ALD). The metabolic products and metabolic events induced by alcohol ingestion are varied in nature and vast in scope. Major research interest has focused on the effects of aldehyde production, oxygen radical formation, mitochondrial membrane permeability defects, endotoxins, and infectious agents as factors in hepatocellular dysfunction and cell death. At the same time, increasing evidence suggests that immune-mediated mechanisms are involved in ALD.

UR - http://www.scopus.com/inward/record.url?scp=84889990794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889990794&partnerID=8YFLogxK

U2 - 10.1007/978-1-59745-518-3_25

DO - 10.1007/978-1-59745-518-3_25

M3 - Chapter

SN - 9781588298188

SP - 309

EP - 321

BT - Liver Immunology

PB - Humana Press

ER -