The histology of bone and dura mater following cranial reconstruction in a rabbit model

John S. Trêves, Brad Bowdino, Lyal Leihrock, Gary Moore, Neil Norton

Research output: Contribution to journalArticle

Abstract

Cranioplasty following skull base surgery is considered the standard of care. Postoperative difficulties such as cerebrospinal leak, aseptic meningitis and headache may be related to substances used in reconstruction. Substances commonly used in cranial reconstruction such as; adipose tissue, muscle, and methyl methacrylate are associated with a significant inflammatory response. Hydroxyapatite cement (BoneSource, Leibinger) has recently received PDA approval for use in humans. Initial reports show good biocompatability but information concerning its interaction with the dura mater is lacking. Data regarding osseointegration in humans is not available. A rabbit model for cranioplasty was used to compare methyl methacrylate, adipose tissue, titanium mesh, muscle and hydroxyapatite cement. Histopathologic analysis was performed twelve weeks after reconstruction. Each material was analyzed for inflammation, fibrosis, foreign body reaction and osseointegration. Hydroxyapatite as compared to the other reconstruction modalities showed good osseointegration with no inflammatory response. Radiographie analysis of cranial reconstruction has been performed to determine the degree of osseointegration.

Original languageEnglish (US)
Number of pages1
JournalSkull Base Surgery
Volume9
Issue numberSUPPL. 1
StatePublished - Dec 1 1999

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Osseointegration
Dura Mater
Histology
Rabbits
Bone and Bones
Methacrylates
Adipose Tissue
Foreign-Body Reaction
Aseptic Meningitis
Muscles
Skull Base
Durapatite
Standard of Care
Titanium
Headache
Fibrosis
Inflammation
hydroxyapatite cement

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Trêves, J. S., Bowdino, B., Leihrock, L., Moore, G., & Norton, N. (1999). The histology of bone and dura mater following cranial reconstruction in a rabbit model. Skull Base Surgery, 9(SUPPL. 1).

The histology of bone and dura mater following cranial reconstruction in a rabbit model. / Trêves, John S.; Bowdino, Brad; Leihrock, Lyal; Moore, Gary; Norton, Neil.

In: Skull Base Surgery, Vol. 9, No. SUPPL. 1, 01.12.1999.

Research output: Contribution to journalArticle

Trêves, JS, Bowdino, B, Leihrock, L, Moore, G & Norton, N 1999, 'The histology of bone and dura mater following cranial reconstruction in a rabbit model', Skull Base Surgery, vol. 9, no. SUPPL. 1.
Trêves, John S. ; Bowdino, Brad ; Leihrock, Lyal ; Moore, Gary ; Norton, Neil. / The histology of bone and dura mater following cranial reconstruction in a rabbit model. In: Skull Base Surgery. 1999 ; Vol. 9, No. SUPPL. 1.
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