The H-ZKkm1 mutation: Nucleotide sequence and comparative analysis

John M. Martinko, Joyce C. Solheim, Jan Geliebter

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Nucleotide sequence analysis of mRNA from the class I murine MHC mutant H-2Kkml has established a site of mutation to be at the codon for amino acid position 152. Complete sequence information for the nucleotides coding for amino acids 136-163 demonstrates an A → C alteration at the codon for amino acid 152, changing Asp (GAT) in Kk to Ala (GCT) in Kkml. Several other murine and human class I MHC variants have similar alterations at amino acid position 152, resulting in altered biological activity. Finally, the pH-2III pseudogene of the H-2k haplotype has a GCT codon at amino acid position 152, suggesting that the GCT codon occurring in Kkml is the result of a gene conversion event.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalMolecular Immunology
Volume24
Issue number2
DOIs
StatePublished - Feb 1987

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Sequence Analysis
Codon
Amino Acids
Mutation
Gene Conversion
Pseudogenes
Haplotypes
Messenger RNA

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

Cite this

The H-ZKkm1 mutation : Nucleotide sequence and comparative analysis. / Martinko, John M.; Solheim, Joyce C.; Geliebter, Jan.

In: Molecular Immunology, Vol. 24, No. 2, 02.1987, p. 197-200.

Research output: Contribution to journalArticle

Martinko, John M. ; Solheim, Joyce C. ; Geliebter, Jan. / The H-ZKkm1 mutation : Nucleotide sequence and comparative analysis. In: Molecular Immunology. 1987 ; Vol. 24, No. 2. pp. 197-200.
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