The Genetic Variation of SORCS1 Is Associated with Late-Onset Alzheimer's Disease in Chinese Han Population

Wei Xu, Jun Xu, Ying Wang, Huidong Tang, Yulei Deng, Rujing Ren, Gang Wang, Wenquan Niu, Jianfang Ma, Yiwen Wu, Jialin Zheng, Shengdi Chen, Jianqing Ding

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Abstract

The variations of SORCS1 gene may play potential key roles in late-onset Alzheimer's disease (LOAD). To evaluate the relationship between the polymorphism of SORCS1 gene and LOAD in the ethnic Han Chinese, we conducted a case-control study to investigate the association between the single-nucleotide polymorphisms (SNPs) in intron 1 of SORCS1 and LOAD in Chinese Han population. Six reported SNPs in intron 1 of SORCS1 were analyzed by Snapshot, genotyping and haplotyping in 236 Chinese LOAD cases and 233 matched controls. The significant differences in frequencies of two SNPs (rs10884402, rs950809) were found between the two groups. In addition, haplotype analyses revealed that, in the LOAD group, the frequency of haplotypes C-C-G-T-C (alleles in order of rs17277986, rs6584777, rs10884402, rs7078098, rs950809 polymorphisms) were significantly higher (Psim<0.0001) while haplotype C-C-A-T-C, C-C-A-C-C, T-T-A-C-C were significantly lower (Psim<0.0001). Our data suggested that the genetic variation of the rs10884402 and rs950809 in intron 1 of SORCS1 was associated with the late-onset AD in the Chinese Han population.

Original languageEnglish (US)
Article numbere63621
JournalPloS one
Volume8
Issue number5
DOIs
StatePublished - May 20 2013

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Xu, W., Xu, J., Wang, Y., Tang, H., Deng, Y., Ren, R., Wang, G., Niu, W., Ma, J., Wu, Y., Zheng, J., Chen, S., & Ding, J. (2013). The Genetic Variation of SORCS1 Is Associated with Late-Onset Alzheimer's Disease in Chinese Han Population. PloS one, 8(5), [e63621]. https://doi.org/10.1371/journal.pone.0063621