The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase

R. Erlandsson, F. Boldog, B. Persson, E. R. Zabarovsky, R. L. Allikmets, J. Sumegi, G. Klein, H. Jornvall

Research output: Contribution to journalArticle

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Abstract

Loss or inactivation of a gene on the short arm of chromosome 3 may contribute to the genesis of renal cell carcinoma. A gene that corresponds to the most frequently lost RFLP site (D3F15S2) is expressed in a variety of human tissues, and at a particularly high level in the kidney. Its expression is markedly reduced in renal cell carcinoma. A database search showed that the gene product is closely related to or identical with acylpeptide hydrolase. The nucleotide identity between the rat acylpeptide hydrolase and the human gene at D3F15S2 is 88%, compatible with normal species differences. It is therefore likely that the human gene product is acylpeptide hydrolase. The renal cell carcinoma is then associated with a decrease of acylpeptide hydrolase activity. The gene may represent a tumor suppressor gene, whose loss contributes to the development of renal cell carcinoma. It might be speculated that it could act e.g. by affecting the activity of a small acetylated growth factor. Alternatively, its decreased expression may merely reflect the impairment of differentiation in RCC, compared to normal kidney. Loss of a linked but irrelevant gene by the 3p deletion is another possibility.

Original languageEnglish (US)
Pages (from-to)1293-1295
Number of pages3
JournalOncogene
Volume6
Issue number7
StatePublished - Sep 6 1991

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Chromosomes, Human, Pair 3
Renal Cell Carcinoma
Genes
Kidney
Gene Deletion
Gene Silencing
Tumor Suppressor Genes
Restriction Fragment Length Polymorphisms
Intercellular Signaling Peptides and Proteins
Nucleotides
acylaminoacyl-peptidase
Databases

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Erlandsson, R., Boldog, F., Persson, B., Zabarovsky, E. R., Allikmets, R. L., Sumegi, J., ... Jornvall, H. (1991). The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. Oncogene, 6(7), 1293-1295.

The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. / Erlandsson, R.; Boldog, F.; Persson, B.; Zabarovsky, E. R.; Allikmets, R. L.; Sumegi, J.; Klein, G.; Jornvall, H.

In: Oncogene, Vol. 6, No. 7, 06.09.1991, p. 1293-1295.

Research output: Contribution to journalArticle

Erlandsson, R, Boldog, F, Persson, B, Zabarovsky, ER, Allikmets, RL, Sumegi, J, Klein, G & Jornvall, H 1991, 'The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase', Oncogene, vol. 6, no. 7, pp. 1293-1295.
Erlandsson R, Boldog F, Persson B, Zabarovsky ER, Allikmets RL, Sumegi J et al. The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. Oncogene. 1991 Sep 6;6(7):1293-1295.
Erlandsson, R. ; Boldog, F. ; Persson, B. ; Zabarovsky, E. R. ; Allikmets, R. L. ; Sumegi, J. ; Klein, G. ; Jornvall, H. / The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. In: Oncogene. 1991 ; Vol. 6, No. 7. pp. 1293-1295.
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