The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo

T. A. Lawson, A. S. Helgeson, C. J. Grandjean, L. Wallcave, D. Nagel

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were higher concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.

Original languageEnglish (US)
Pages (from-to)845-849
Number of pages5
JournalCarcinogenesis
Volume2
Issue number9
DOIs
StatePublished - Dec 1 1981

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nitrosobis(2-oxopropyl)amine
Mesocricetus
Salivary Glands
Cricetinae
Amines
Pancreas
Injections
Liver

ASJC Scopus subject areas

  • Cancer Research

Cite this

Lawson, T. A., Helgeson, A. S., Grandjean, C. J., Wallcave, L., & Nagel, D. (1981). The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo. Carcinogenesis, 2(9), 845-849. https://doi.org/10.1093/carcin/2.9.845

The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo. / Lawson, T. A.; Helgeson, A. S.; Grandjean, C. J.; Wallcave, L.; Nagel, D.

In: Carcinogenesis, Vol. 2, No. 9, 01.12.1981, p. 845-849.

Research output: Contribution to journalArticle

Lawson, TA, Helgeson, AS, Grandjean, CJ, Wallcave, L & Nagel, D 1981, 'The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo', Carcinogenesis, vol. 2, no. 9, pp. 845-849. https://doi.org/10.1093/carcin/2.9.845
Lawson, T. A. ; Helgeson, A. S. ; Grandjean, C. J. ; Wallcave, L. ; Nagel, D. / The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo. In: Carcinogenesis. 1981 ; Vol. 2, No. 9. pp. 845-849.
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