The expanding role for retinoid signaling in heart development

Loretta H Jophlin, Elizabeth G. Burton, Bonnie A. Brooks, Steven W. Kubalak

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

The importance of retinoid signaling during cardiac development has long been appreciated, but recently has become a rapidly expanding field of research. Experiments performed over 50 years ago showed that too much or too little maternal intake of vitamin A proved detrimental for embryos, resulting in a cadre of predictable cardiac developmental defects. Germline and conditional knockout mice have revealed which molecular players in the vitamin A signaling cascade are potentially responsible for regulating specific developmental events, and many of these molecules have been temporally and spatially characterized. It is evident that intact and controlled retinoid signaling is necessary for each stage of cardiac development to proceed normally, including cardiac lineage determination, heart tube formation, looping, epicardium formation, ventricular maturation, chamber and outflow tract septation, and coronary arteriogenesis. This review summarizes many of the significant milestones in this field and particular attention is given to recently uncovered cross-talk between retinoid signaling and other developmentally significant pathways. It is our hope that this review of the role of retinoid signaling during formation, remodeling, and maturation of the developing heart will serve as a tool for future discoveries.

Original languageEnglish (US)
Pages (from-to)194-211
Number of pages18
JournalTheScientificWorldJournal
Volume8
DOIs
StatePublished - Feb 25 2008

Fingerprint

Retinoids
Vitamin A
vitamin
maturation
Pericardium
Knockout Mice
Embryonic Structures
Mothers
defect
embryo
outflow
Defects
Research
Molecules
experiment
Experiments

Keywords

  • Cardiac development
  • Embryo
  • Heart
  • Retinoic acid receptor (RAR)
  • Retinoid X receptor (RXR)
  • Retinoids
  • Signaling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Jophlin, L. H., Burton, E. G., Brooks, B. A., & Kubalak, S. W. (2008). The expanding role for retinoid signaling in heart development. TheScientificWorldJournal, 8, 194-211. https://doi.org/10.1100/tsw.2008.39

The expanding role for retinoid signaling in heart development. / Jophlin, Loretta H; Burton, Elizabeth G.; Brooks, Bonnie A.; Kubalak, Steven W.

In: TheScientificWorldJournal, Vol. 8, 25.02.2008, p. 194-211.

Research output: Contribution to journalReview article

Jophlin, LH, Burton, EG, Brooks, BA & Kubalak, SW 2008, 'The expanding role for retinoid signaling in heart development', TheScientificWorldJournal, vol. 8, pp. 194-211. https://doi.org/10.1100/tsw.2008.39
Jophlin, Loretta H ; Burton, Elizabeth G. ; Brooks, Bonnie A. ; Kubalak, Steven W. / The expanding role for retinoid signaling in heart development. In: TheScientificWorldJournal. 2008 ; Vol. 8. pp. 194-211.
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