The effects of temperature and acute alcohol intoxication on brain stem auditory evoked potentials in the cat

Timothy A Jones, J. J. Stockard, W. J. Weidner

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The effects of core temperature changes (less than 1°C) and acute ethanol intoxication (100-400 mg%) on brain stem auditory evoked potentials in cats were studied independently - then together - to distinguish between a putative direct pharmacological action of ethanol on brain stem auditory neurons, as reflected in reported BAEP latency changes, and an indirect action of ethanol mediated through slight changes in central temperatures. The results suggest that the reported BAEP latency effects are attributable, largely if not entirely, to the second mechanism above. No significant temperature-independent BAEP latency alterations occurred at any sublethal blood ethanol concentration or in one dosage that subsequently proved fatal. These findings do not exclude a direct ethanol effect on brain stem auditory neurons but provide no evidence for a temperature-independent effect. Knowledge of secondary BAEP temperature effects associated with drug administration is crucial to proper interpretation of BAEPs in both experimental and clinical applications.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalElectroencephalography and Clinical Neurophysiology
Volume49
Issue number1-2
DOIs
StatePublished - Jan 1 1980

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Alcoholic Intoxication
Brain Stem Auditory Evoked Potentials
Cats
Ethanol
Temperature
Brain Stem
Neurons
Pharmacology
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The effects of temperature and acute alcohol intoxication on brain stem auditory evoked potentials in the cat. / Jones, Timothy A; Stockard, J. J.; Weidner, W. J.

In: Electroencephalography and Clinical Neurophysiology, Vol. 49, No. 1-2, 01.01.1980, p. 23-30.

Research output: Contribution to journalArticle

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