The effects of scopolamine on extinction and spontaneous recovery

Barbara J. Morley, Raymond Russin

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Abstract

The effects of scopolamine hydrobromide on baseline extinction levels and spontaneous recovery were assessed. Rats were trained on one of four reinforcement schedules (CRF, FR 10, FR 20, FR 40) with either food or water reinforcement. Scopolamine increased response rates in extinction and spontaneous recovery following training on all four schedules when the reinforcer was water, but had no effect on responding previously maintained by food. The results are discussed in terms of the limitations of a general theory of a cholinergic system mediating all suppressed behavior and the effects of anticholinergic drugs on central thirst mechanisms and consummatory behavior.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalPsychopharmacology
Volume56
Issue number3
DOIs
StatePublished - Jan 1 1978

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Keywords

  • Disinhibition
  • Extinction
  • Schedules of reinforcement
  • Scopolamine
  • Spontaneous recovery

ASJC Scopus subject areas

  • Pharmacology

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