The effects of mustine hydrochloride on the colony forming units of murine bone marrow

J. G. Sharp, D. Brynmor Thomas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The sequence of changes in the CFU content of murine bone marrow has been studied during the brief period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
JournalActa Haematologica
Volume46
Issue number5
DOIs
StatePublished - Jan 1 1971

Fingerprint

Mechlorethamine
Diaphyses
Thigh
Stem Cells
Bone Marrow

Keywords

  • Colony forming units
  • Mouse bone marrow
  • Nitrogen mustard

ASJC Scopus subject areas

  • Hematology

Cite this

The effects of mustine hydrochloride on the colony forming units of murine bone marrow. / Sharp, J. G.; Thomas, D. Brynmor.

In: Acta Haematologica, Vol. 46, No. 5, 01.01.1971, p. 271-274.

Research output: Contribution to journalArticle

@article{95fea5a2281c4d1ab07adf792159f723,
title = "The effects of mustine hydrochloride on the colony forming units of murine bone marrow",
abstract = "The sequence of changes in the CFU content of murine bone marrow has been studied during the brief period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.",
keywords = "Colony forming units, Mouse bone marrow, Nitrogen mustard",
author = "Sharp, {J. G.} and Thomas, {D. Brynmor}",
year = "1971",
month = "1",
day = "1",
doi = "10.1159/000208586",
language = "English (US)",
volume = "46",
pages = "271--274",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - The effects of mustine hydrochloride on the colony forming units of murine bone marrow

AU - Sharp, J. G.

AU - Thomas, D. Brynmor

PY - 1971/1/1

Y1 - 1971/1/1

N2 - The sequence of changes in the CFU content of murine bone marrow has been studied during the brief period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.

AB - The sequence of changes in the CFU content of murine bone marrow has been studied during the brief period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.

KW - Colony forming units

KW - Mouse bone marrow

KW - Nitrogen mustard

UR - http://www.scopus.com/inward/record.url?scp=0015195948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015195948&partnerID=8YFLogxK

U2 - 10.1159/000208586

DO - 10.1159/000208586

M3 - Article

C2 - 5005905

AN - SCOPUS:0015195948

VL - 46

SP - 271

EP - 274

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 5

ER -