The effects of endothelin-1 on coronary perfusion pressure during cardiopulmonary resuscitation in a canine model

Daniel J DeBehnke, D. Spreng, L. L. Wickman, D. T. Crowe

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: To study the hemodynamic effects of exogenously administered endothelin-1 (ET-1), a peptide produced by endothelial cells with potent non-adrenergically mediated vasoconstrictor properties. Methods: A prospective drug intervention study was carried out in a resuscitation research laboratory. Fifteen mixed-breed dogs were anesthetized aud instrumented for hemodynamic monitoring. Asphyxia arrest was produced by clamping the endotracheal tube. Hemodynamic data were collected continuously. Following loss of aortic fluctuations monitored by thoracic aortic catheter, the animals remained in pulseless electrical activity (PEA) for 10 minutes. After 10 minutes of no-flow PEA, closed-chest CPR was begun and the animals were randomized to one of three treatment groups (EPI, 0.02 mg/kg epinephrine IV every 3 minutes; ENDO, 100 μg ET-I IV at 0 minutes; and EPI/ENDO, a combination of the EPI and ENDO treatments). Results: ENDO and EPI alone produced similar coronary perfusion pressures (CPPs). The EPI/ENDO combination produced significantly improved CPP compared with that of either EPI or ENDO alone. In the EPI group, the best mean CPP was 16 ± 14 mm Hg and occurred 7 minutes after drug administration. In the ENDO group, the best mean CPP was 28 ± 7 mm Hg and occurred 13 minutes after drug administration. In the EPI/ENDO combination group, the best mean CPP was 61 ± 37 mm Hg and occurred 7 minutes after drug administration (p < 0.05 compared with the EPI and ENDO groups alone). Conclusion: ET-1 is a potent vasoconstrictor. The combination of EPI and ENDO significantly improved CPP compared with that for either agent alone. ET-1 should be investigated further as a vasoconstrictor in cardiac arrest.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalAcademic Emergency Medicine
Volume3
Issue number2
DOIs
StatePublished - Jan 1 1996

Fingerprint

Cardiopulmonary Resuscitation
Endothelin-1
Canidae
Perfusion
Pressure
Vasoconstrictor Agents
Hemodynamics
Pharmaceutical Preparations
Thorax
Asphyxia
Heart Arrest
Constriction
Resuscitation
Epinephrine
Catheters
Endothelial Cells
Dogs
Peptides
Therapeutics
Research

Keywords

  • CPR
  • asphyxia
  • cardiac arrest
  • coronary perfusion pressure
  • endothelin
  • resuscitation

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

The effects of endothelin-1 on coronary perfusion pressure during cardiopulmonary resuscitation in a canine model. / DeBehnke, Daniel J; Spreng, D.; Wickman, L. L.; Crowe, D. T.

In: Academic Emergency Medicine, Vol. 3, No. 2, 01.01.1996, p. 137-141.

Research output: Contribution to journalArticle

DeBehnke, Daniel J ; Spreng, D. ; Wickman, L. L. ; Crowe, D. T. / The effects of endothelin-1 on coronary perfusion pressure during cardiopulmonary resuscitation in a canine model. In: Academic Emergency Medicine. 1996 ; Vol. 3, No. 2. pp. 137-141.
@article{2c2eb6a005144cadae1678d96ea44377,
title = "The effects of endothelin-1 on coronary perfusion pressure during cardiopulmonary resuscitation in a canine model",
abstract = "Objective: To study the hemodynamic effects of exogenously administered endothelin-1 (ET-1), a peptide produced by endothelial cells with potent non-adrenergically mediated vasoconstrictor properties. Methods: A prospective drug intervention study was carried out in a resuscitation research laboratory. Fifteen mixed-breed dogs were anesthetized aud instrumented for hemodynamic monitoring. Asphyxia arrest was produced by clamping the endotracheal tube. Hemodynamic data were collected continuously. Following loss of aortic fluctuations monitored by thoracic aortic catheter, the animals remained in pulseless electrical activity (PEA) for 10 minutes. After 10 minutes of no-flow PEA, closed-chest CPR was begun and the animals were randomized to one of three treatment groups (EPI, 0.02 mg/kg epinephrine IV every 3 minutes; ENDO, 100 μg ET-I IV at 0 minutes; and EPI/ENDO, a combination of the EPI and ENDO treatments). Results: ENDO and EPI alone produced similar coronary perfusion pressures (CPPs). The EPI/ENDO combination produced significantly improved CPP compared with that of either EPI or ENDO alone. In the EPI group, the best mean CPP was 16 ± 14 mm Hg and occurred 7 minutes after drug administration. In the ENDO group, the best mean CPP was 28 ± 7 mm Hg and occurred 13 minutes after drug administration. In the EPI/ENDO combination group, the best mean CPP was 61 ± 37 mm Hg and occurred 7 minutes after drug administration (p < 0.05 compared with the EPI and ENDO groups alone). Conclusion: ET-1 is a potent vasoconstrictor. The combination of EPI and ENDO significantly improved CPP compared with that for either agent alone. ET-1 should be investigated further as a vasoconstrictor in cardiac arrest.",
keywords = "CPR, asphyxia, cardiac arrest, coronary perfusion pressure, endothelin, resuscitation",
author = "DeBehnke, {Daniel J} and D. Spreng and Wickman, {L. L.} and Crowe, {D. T.}",
year = "1996",
month = "1",
day = "1",
doi = "10.1111/j.1553-2712.1996.tb03401.x",
language = "English (US)",
volume = "3",
pages = "137--141",
journal = "Academic Emergency Medicine",
issn = "1069-6563",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - The effects of endothelin-1 on coronary perfusion pressure during cardiopulmonary resuscitation in a canine model

AU - DeBehnke, Daniel J

AU - Spreng, D.

AU - Wickman, L. L.

AU - Crowe, D. T.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Objective: To study the hemodynamic effects of exogenously administered endothelin-1 (ET-1), a peptide produced by endothelial cells with potent non-adrenergically mediated vasoconstrictor properties. Methods: A prospective drug intervention study was carried out in a resuscitation research laboratory. Fifteen mixed-breed dogs were anesthetized aud instrumented for hemodynamic monitoring. Asphyxia arrest was produced by clamping the endotracheal tube. Hemodynamic data were collected continuously. Following loss of aortic fluctuations monitored by thoracic aortic catheter, the animals remained in pulseless electrical activity (PEA) for 10 minutes. After 10 minutes of no-flow PEA, closed-chest CPR was begun and the animals were randomized to one of three treatment groups (EPI, 0.02 mg/kg epinephrine IV every 3 minutes; ENDO, 100 μg ET-I IV at 0 minutes; and EPI/ENDO, a combination of the EPI and ENDO treatments). Results: ENDO and EPI alone produced similar coronary perfusion pressures (CPPs). The EPI/ENDO combination produced significantly improved CPP compared with that of either EPI or ENDO alone. In the EPI group, the best mean CPP was 16 ± 14 mm Hg and occurred 7 minutes after drug administration. In the ENDO group, the best mean CPP was 28 ± 7 mm Hg and occurred 13 minutes after drug administration. In the EPI/ENDO combination group, the best mean CPP was 61 ± 37 mm Hg and occurred 7 minutes after drug administration (p < 0.05 compared with the EPI and ENDO groups alone). Conclusion: ET-1 is a potent vasoconstrictor. The combination of EPI and ENDO significantly improved CPP compared with that for either agent alone. ET-1 should be investigated further as a vasoconstrictor in cardiac arrest.

AB - Objective: To study the hemodynamic effects of exogenously administered endothelin-1 (ET-1), a peptide produced by endothelial cells with potent non-adrenergically mediated vasoconstrictor properties. Methods: A prospective drug intervention study was carried out in a resuscitation research laboratory. Fifteen mixed-breed dogs were anesthetized aud instrumented for hemodynamic monitoring. Asphyxia arrest was produced by clamping the endotracheal tube. Hemodynamic data were collected continuously. Following loss of aortic fluctuations monitored by thoracic aortic catheter, the animals remained in pulseless electrical activity (PEA) for 10 minutes. After 10 minutes of no-flow PEA, closed-chest CPR was begun and the animals were randomized to one of three treatment groups (EPI, 0.02 mg/kg epinephrine IV every 3 minutes; ENDO, 100 μg ET-I IV at 0 minutes; and EPI/ENDO, a combination of the EPI and ENDO treatments). Results: ENDO and EPI alone produced similar coronary perfusion pressures (CPPs). The EPI/ENDO combination produced significantly improved CPP compared with that of either EPI or ENDO alone. In the EPI group, the best mean CPP was 16 ± 14 mm Hg and occurred 7 minutes after drug administration. In the ENDO group, the best mean CPP was 28 ± 7 mm Hg and occurred 13 minutes after drug administration. In the EPI/ENDO combination group, the best mean CPP was 61 ± 37 mm Hg and occurred 7 minutes after drug administration (p < 0.05 compared with the EPI and ENDO groups alone). Conclusion: ET-1 is a potent vasoconstrictor. The combination of EPI and ENDO significantly improved CPP compared with that for either agent alone. ET-1 should be investigated further as a vasoconstrictor in cardiac arrest.

KW - CPR

KW - asphyxia

KW - cardiac arrest

KW - coronary perfusion pressure

KW - endothelin

KW - resuscitation

UR - http://www.scopus.com/inward/record.url?scp=0029927417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029927417&partnerID=8YFLogxK

U2 - 10.1111/j.1553-2712.1996.tb03401.x

DO - 10.1111/j.1553-2712.1996.tb03401.x

M3 - Article

VL - 3

SP - 137

EP - 141

JO - Academic Emergency Medicine

JF - Academic Emergency Medicine

SN - 1069-6563

IS - 2

ER -