The effects of dopamine blockade on the renal response to volume expansion in the primate

R. Iaffaldano, J. Eye, J. P. Gilmore, K. G. Cornish

Research output: Contribution to journalArticle

Abstract

It has been reported that dopamine antagonists block the natriuretic but not the diuretic response to volume expansion in man. In order to examine this, anesthetized monkeys (pentobarbital) were volume expanded with isotonic dextran (20% of estimated blood volume) either with (n = 7) or without (n = 8) dopamine blockade (metoclopramide HCl 5 mg followed by an infusion of 10 mg/hr). Similar experiments were done in conscious chair restrained monkeys (5 control, 5 block). In the anesthetized monkey, dopamine blockade did not block the diuretic and natriuretic response to blood volume expansion. No significant changes were observed in any other renal or cardiovascular variables. In four of six experiments in the conscious monkey, the dopamine antagonist blocked the natriuretic response to volume expansion and reduced the diuretic response. In the other two experiments, the antagonist was without effect on the response. It is concluded that a dopaminergic system is involved in the control of blood volume and that this system is inhibited by pentobarbital anesthetic. Supported by NIH grants #HL-13427, #HL-27371 and #HL-32480 and a Nebr. Heart Grant-in-Aid.

Original languageEnglish (US)
Pages (from-to)No. 7836
JournalFederation Proceedings
Volume44
Issue number5
StatePublished - Jan 1 1985

Fingerprint

Primates
Haplorhini
Dopamine
Blood Volume
Diuretics
Kidney
Dopamine Antagonists
Organized Financing
Pentobarbital
Metoclopramide
Dextrans
Anesthetics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Iaffaldano, R., Eye, J., Gilmore, J. P., & Cornish, K. G. (1985). The effects of dopamine blockade on the renal response to volume expansion in the primate. Federation Proceedings, 44(5), No. 7836.

The effects of dopamine blockade on the renal response to volume expansion in the primate. / Iaffaldano, R.; Eye, J.; Gilmore, J. P.; Cornish, K. G.

In: Federation Proceedings, Vol. 44, No. 5, 01.01.1985, p. No. 7836.

Research output: Contribution to journalArticle

Iaffaldano, R, Eye, J, Gilmore, JP & Cornish, KG 1985, 'The effects of dopamine blockade on the renal response to volume expansion in the primate', Federation Proceedings, vol. 44, no. 5, pp. No. 7836.
Iaffaldano R, Eye J, Gilmore JP, Cornish KG. The effects of dopamine blockade on the renal response to volume expansion in the primate. Federation Proceedings. 1985 Jan 1;44(5):No. 7836.
Iaffaldano, R. ; Eye, J. ; Gilmore, J. P. ; Cornish, K. G. / The effects of dopamine blockade on the renal response to volume expansion in the primate. In: Federation Proceedings. 1985 ; Vol. 44, No. 5. pp. No. 7836.
@article{7c357224ec0047e88da3823e674c65cc,
title = "The effects of dopamine blockade on the renal response to volume expansion in the primate",
abstract = "It has been reported that dopamine antagonists block the natriuretic but not the diuretic response to volume expansion in man. In order to examine this, anesthetized monkeys (pentobarbital) were volume expanded with isotonic dextran (20{\%} of estimated blood volume) either with (n = 7) or without (n = 8) dopamine blockade (metoclopramide HCl 5 mg followed by an infusion of 10 mg/hr). Similar experiments were done in conscious chair restrained monkeys (5 control, 5 block). In the anesthetized monkey, dopamine blockade did not block the diuretic and natriuretic response to blood volume expansion. No significant changes were observed in any other renal or cardiovascular variables. In four of six experiments in the conscious monkey, the dopamine antagonist blocked the natriuretic response to volume expansion and reduced the diuretic response. In the other two experiments, the antagonist was without effect on the response. It is concluded that a dopaminergic system is involved in the control of blood volume and that this system is inhibited by pentobarbital anesthetic. Supported by NIH grants #HL-13427, #HL-27371 and #HL-32480 and a Nebr. Heart Grant-in-Aid.",
author = "R. Iaffaldano and J. Eye and Gilmore, {J. P.} and Cornish, {K. G.}",
year = "1985",
month = "1",
day = "1",
language = "English (US)",
volume = "44",
pages = "No. 7836",
journal = "Federation Proceedings",
issn = "0014-9446",
number = "5",

}

TY - JOUR

T1 - The effects of dopamine blockade on the renal response to volume expansion in the primate

AU - Iaffaldano, R.

AU - Eye, J.

AU - Gilmore, J. P.

AU - Cornish, K. G.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - It has been reported that dopamine antagonists block the natriuretic but not the diuretic response to volume expansion in man. In order to examine this, anesthetized monkeys (pentobarbital) were volume expanded with isotonic dextran (20% of estimated blood volume) either with (n = 7) or without (n = 8) dopamine blockade (metoclopramide HCl 5 mg followed by an infusion of 10 mg/hr). Similar experiments were done in conscious chair restrained monkeys (5 control, 5 block). In the anesthetized monkey, dopamine blockade did not block the diuretic and natriuretic response to blood volume expansion. No significant changes were observed in any other renal or cardiovascular variables. In four of six experiments in the conscious monkey, the dopamine antagonist blocked the natriuretic response to volume expansion and reduced the diuretic response. In the other two experiments, the antagonist was without effect on the response. It is concluded that a dopaminergic system is involved in the control of blood volume and that this system is inhibited by pentobarbital anesthetic. Supported by NIH grants #HL-13427, #HL-27371 and #HL-32480 and a Nebr. Heart Grant-in-Aid.

AB - It has been reported that dopamine antagonists block the natriuretic but not the diuretic response to volume expansion in man. In order to examine this, anesthetized monkeys (pentobarbital) were volume expanded with isotonic dextran (20% of estimated blood volume) either with (n = 7) or without (n = 8) dopamine blockade (metoclopramide HCl 5 mg followed by an infusion of 10 mg/hr). Similar experiments were done in conscious chair restrained monkeys (5 control, 5 block). In the anesthetized monkey, dopamine blockade did not block the diuretic and natriuretic response to blood volume expansion. No significant changes were observed in any other renal or cardiovascular variables. In four of six experiments in the conscious monkey, the dopamine antagonist blocked the natriuretic response to volume expansion and reduced the diuretic response. In the other two experiments, the antagonist was without effect on the response. It is concluded that a dopaminergic system is involved in the control of blood volume and that this system is inhibited by pentobarbital anesthetic. Supported by NIH grants #HL-13427, #HL-27371 and #HL-32480 and a Nebr. Heart Grant-in-Aid.

UR - http://www.scopus.com/inward/record.url?scp=0021984292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021984292&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0021984292

VL - 44

SP - No. 7836

JO - Federation Proceedings

JF - Federation Proceedings

SN - 0014-9446

IS - 5

ER -