The effects of dietary amino acids on hepatic l-asparagine synthetase

Rodney Smith Markin, Sheldon M. Schuster

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Rats were fed Roger's synthetic amino acid diets, complete or without asparagine, aspartate, or glutamate, for 2 weeks. Hepatic and serum amino acid content and hepatic asparagine synthetase were assayed before and after the test diets were administered. Special attention was paid to the multiple forms of asparagine synthetas present. Rats fed the test diet without asparagine exhibited high molecular weight (110,000) α-form and intermediate molecular weight (57,000) β-form of asparagine synthetase. Rats fed the complete test diet and the test diet without asparatate exhibited only the β-form of the enzyme. Rats fed the test diet without glutamate exhibited no enzyme activity. These data are related to the hepatic amino acid levels and to the role of asparagine and asparagine synthetase in amino acid homeostasis.

Original languageEnglish (US)
Pages (from-to)891-896
Number of pages6
JournalMetabolism
Volume33
Issue number10
DOIs
StatePublished - Jan 1 1984

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Aspartate-Ammonia Ligase
Asparagine
Diet
Amino Acids
Liver
Glutamic Acid
Molecular Weight
Enzymes
Aspartic Acid
Homeostasis
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The effects of dietary amino acids on hepatic l-asparagine synthetase. / Markin, Rodney Smith; Schuster, Sheldon M.

In: Metabolism, Vol. 33, No. 10, 01.01.1984, p. 891-896.

Research output: Contribution to journalArticle

Markin, Rodney Smith ; Schuster, Sheldon M. / The effects of dietary amino acids on hepatic l-asparagine synthetase. In: Metabolism. 1984 ; Vol. 33, No. 10. pp. 891-896.
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