The effects of child abuse and neglect on cognitive functioning in adulthood

Felicia Gould, Jennifer L Clarke, Christine Heim, Philip D. Harvey, Matthias Majer, Charles B. Nemeroff

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Aims: Recent research has revealed that early life trauma (ELS), including abuse (sexual and/or physical) and neglect, produce lasting changes in the CNS. We posited that cognitive deficits, often observed in psychiatric patients, result, in part, due to the neurobiological consequences of ELS. Additionally, we hypothesized that the nature and magnitude of cognitive deficits would differ according to the subtype of ELS experienced. Method: The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to assess neurocognitive functioning in 93 subjects (60 with ELS and 33 without). In the patients with a history of ELS, 35% and 16.7%, respectively, met criteria for current major depression and PTSD. Results: Significant associations between ELS status and CANTAB measures of memory and executive and emotional functioning were found. Conclusions: These data suggest that exposure to ELS results in a cascade of neurobiological changes associated with cognitive deficits in adulthood that vary according to the type of trauma experienced.

Original languageEnglish (US)
Pages (from-to)500-506
Number of pages7
JournalJournal of Psychiatric Research
Volume46
Issue number4
DOIs
StatePublished - Jan 1 2012

Fingerprint

Neuropsychological Tests
Child Abuse
Sex Offenses
Wounds and Injuries
Post-Traumatic Stress Disorders
Psychiatry
Depression
Research
Adulthood
Neglect
Trauma
Battery

Keywords

  • Child abuse
  • Cognition
  • ELS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

The effects of child abuse and neglect on cognitive functioning in adulthood. / Gould, Felicia; Clarke, Jennifer L; Heim, Christine; Harvey, Philip D.; Majer, Matthias; Nemeroff, Charles B.

In: Journal of Psychiatric Research, Vol. 46, No. 4, 01.01.2012, p. 500-506.

Research output: Contribution to journalArticle

Gould, Felicia ; Clarke, Jennifer L ; Heim, Christine ; Harvey, Philip D. ; Majer, Matthias ; Nemeroff, Charles B. / The effects of child abuse and neglect on cognitive functioning in adulthood. In: Journal of Psychiatric Research. 2012 ; Vol. 46, No. 4. pp. 500-506.
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