The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: A 24-month randomized controlled trial

Nancy Lauraine Waltman, Janice J Twiss, C. D. Ott, G. J. Gross, A. M. Lindsey, Timothy Eisdell Moore, K. Berg, Kevin A Kupzyk

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Abstract

This study examined whether 24 months of weight training exercises enhanced the effectiveness of risedronate, calcium, and vitamin D in maintaining or improving bone mineral density (BMD) in 223 postmenopausal breast cancer survivors. Subjects who were ≥50% adherent to exercise had no improvement in BMD but were less likely to lose BMD. Introduction: This study examined whether (1) postmenopausal breast cancer survivors (BCS) with bone loss taking 24 months of risedronate, calcium, and vitamin D had increased bone mineral density (BMD) at the total hip, femoral neck, L1-L4 spine, total radius and 33% radius, and decreased bone turnover; (2) subjects who also participated in strength/weight training (ST) exercises had greater increases in BMD and greater decreases in bone turnover; and (3) subjects who also exercised were more likely to preserve (at least maintain) BMD. Methods: Postmenopausal BCS (223) were randomly assigned to exercise plus medication or medication only groups. Both groups received 24 months of 1,200 mg of calcium and 400 IU of vitamin D daily and 35 mg of risedronate weekly, and the exercise group additionally had ST exercises twice weekly. Results: After 24 months, women who took medications without exercising had significant improvements in BMD at the total hip (+1.81%) and spine (+2.85%) and significant decreases in Alkphase B (-8.7%) and serum NTx (-16.7%). Women who also exercised had additional increases in BMD at the femoral neck (+0.29%), total hip (+0.34%), spine (+0.23%), total radius (+0.30%), and additional decreases in Alkphase B (-2.4%) and Serum NTx (-6.5%). Additional changes in BMD and bone turnover with exercise were not significant. Subjects who were ≥50% adherent to exercise were less likely to lose BMD at the total hip (chi-square [1]=4.66, p=0.03) and femoral neck (chi-square [1]=4.63, p=0.03). Conclusion: Strength/weight training exercises may prevent loss of BMD in postmenopausal BCS at risk for bone loss.

Original languageEnglish (US)
Pages (from-to)1361-1369
Number of pages9
JournalOsteoporosis International
Volume21
Issue number8
DOIs
StatePublished - Aug 1 2010

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Bone Remodeling
Bone Density
Survivors
Randomized Controlled Trials
Breast Neoplasms
Weights and Measures
Bone and Bones
Exercise
Resistance Training
Hip
Femur Neck
Vitamin D
Spine
Calcium
Serum

Keywords

  • Bone mineral density
  • Bone turnover
  • Postmenopausal breast cancer survivors
  • Strength/weight training exercises

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

@article{08321789ae4946cb98161b7888fec4c5,
title = "The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: A 24-month randomized controlled trial",
abstract = "This study examined whether 24 months of weight training exercises enhanced the effectiveness of risedronate, calcium, and vitamin D in maintaining or improving bone mineral density (BMD) in 223 postmenopausal breast cancer survivors. Subjects who were ≥50{\%} adherent to exercise had no improvement in BMD but were less likely to lose BMD. Introduction: This study examined whether (1) postmenopausal breast cancer survivors (BCS) with bone loss taking 24 months of risedronate, calcium, and vitamin D had increased bone mineral density (BMD) at the total hip, femoral neck, L1-L4 spine, total radius and 33{\%} radius, and decreased bone turnover; (2) subjects who also participated in strength/weight training (ST) exercises had greater increases in BMD and greater decreases in bone turnover; and (3) subjects who also exercised were more likely to preserve (at least maintain) BMD. Methods: Postmenopausal BCS (223) were randomly assigned to exercise plus medication or medication only groups. Both groups received 24 months of 1,200 mg of calcium and 400 IU of vitamin D daily and 35 mg of risedronate weekly, and the exercise group additionally had ST exercises twice weekly. Results: After 24 months, women who took medications without exercising had significant improvements in BMD at the total hip (+1.81{\%}) and spine (+2.85{\%}) and significant decreases in Alkphase B (-8.7{\%}) and serum NTx (-16.7{\%}). Women who also exercised had additional increases in BMD at the femoral neck (+0.29{\%}), total hip (+0.34{\%}), spine (+0.23{\%}), total radius (+0.30{\%}), and additional decreases in Alkphase B (-2.4{\%}) and Serum NTx (-6.5{\%}). Additional changes in BMD and bone turnover with exercise were not significant. Subjects who were ≥50{\%} adherent to exercise were less likely to lose BMD at the total hip (chi-square [1]=4.66, p=0.03) and femoral neck (chi-square [1]=4.63, p=0.03). Conclusion: Strength/weight training exercises may prevent loss of BMD in postmenopausal BCS at risk for bone loss.",
keywords = "Bone mineral density, Bone turnover, Postmenopausal breast cancer survivors, Strength/weight training exercises",
author = "Waltman, {Nancy Lauraine} and Twiss, {Janice J} and Ott, {C. D.} and Gross, {G. J.} and Lindsey, {A. M.} and Moore, {Timothy Eisdell} and K. Berg and Kupzyk, {Kevin A}",
year = "2010",
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TY - JOUR

T1 - The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss

T2 - A 24-month randomized controlled trial

AU - Waltman, Nancy Lauraine

AU - Twiss, Janice J

AU - Ott, C. D.

AU - Gross, G. J.

AU - Lindsey, A. M.

AU - Moore, Timothy Eisdell

AU - Berg, K.

AU - Kupzyk, Kevin A

PY - 2010/8/1

Y1 - 2010/8/1

N2 - This study examined whether 24 months of weight training exercises enhanced the effectiveness of risedronate, calcium, and vitamin D in maintaining or improving bone mineral density (BMD) in 223 postmenopausal breast cancer survivors. Subjects who were ≥50% adherent to exercise had no improvement in BMD but were less likely to lose BMD. Introduction: This study examined whether (1) postmenopausal breast cancer survivors (BCS) with bone loss taking 24 months of risedronate, calcium, and vitamin D had increased bone mineral density (BMD) at the total hip, femoral neck, L1-L4 spine, total radius and 33% radius, and decreased bone turnover; (2) subjects who also participated in strength/weight training (ST) exercises had greater increases in BMD and greater decreases in bone turnover; and (3) subjects who also exercised were more likely to preserve (at least maintain) BMD. Methods: Postmenopausal BCS (223) were randomly assigned to exercise plus medication or medication only groups. Both groups received 24 months of 1,200 mg of calcium and 400 IU of vitamin D daily and 35 mg of risedronate weekly, and the exercise group additionally had ST exercises twice weekly. Results: After 24 months, women who took medications without exercising had significant improvements in BMD at the total hip (+1.81%) and spine (+2.85%) and significant decreases in Alkphase B (-8.7%) and serum NTx (-16.7%). Women who also exercised had additional increases in BMD at the femoral neck (+0.29%), total hip (+0.34%), spine (+0.23%), total radius (+0.30%), and additional decreases in Alkphase B (-2.4%) and Serum NTx (-6.5%). Additional changes in BMD and bone turnover with exercise were not significant. Subjects who were ≥50% adherent to exercise were less likely to lose BMD at the total hip (chi-square [1]=4.66, p=0.03) and femoral neck (chi-square [1]=4.63, p=0.03). Conclusion: Strength/weight training exercises may prevent loss of BMD in postmenopausal BCS at risk for bone loss.

AB - This study examined whether 24 months of weight training exercises enhanced the effectiveness of risedronate, calcium, and vitamin D in maintaining or improving bone mineral density (BMD) in 223 postmenopausal breast cancer survivors. Subjects who were ≥50% adherent to exercise had no improvement in BMD but were less likely to lose BMD. Introduction: This study examined whether (1) postmenopausal breast cancer survivors (BCS) with bone loss taking 24 months of risedronate, calcium, and vitamin D had increased bone mineral density (BMD) at the total hip, femoral neck, L1-L4 spine, total radius and 33% radius, and decreased bone turnover; (2) subjects who also participated in strength/weight training (ST) exercises had greater increases in BMD and greater decreases in bone turnover; and (3) subjects who also exercised were more likely to preserve (at least maintain) BMD. Methods: Postmenopausal BCS (223) were randomly assigned to exercise plus medication or medication only groups. Both groups received 24 months of 1,200 mg of calcium and 400 IU of vitamin D daily and 35 mg of risedronate weekly, and the exercise group additionally had ST exercises twice weekly. Results: After 24 months, women who took medications without exercising had significant improvements in BMD at the total hip (+1.81%) and spine (+2.85%) and significant decreases in Alkphase B (-8.7%) and serum NTx (-16.7%). Women who also exercised had additional increases in BMD at the femoral neck (+0.29%), total hip (+0.34%), spine (+0.23%), total radius (+0.30%), and additional decreases in Alkphase B (-2.4%) and Serum NTx (-6.5%). Additional changes in BMD and bone turnover with exercise were not significant. Subjects who were ≥50% adherent to exercise were less likely to lose BMD at the total hip (chi-square [1]=4.66, p=0.03) and femoral neck (chi-square [1]=4.63, p=0.03). Conclusion: Strength/weight training exercises may prevent loss of BMD in postmenopausal BCS at risk for bone loss.

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KW - Bone turnover

KW - Postmenopausal breast cancer survivors

KW - Strength/weight training exercises

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