The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat

Frederick A. Wilson, Dean Lowell Antonson, Blaine L. Hart, Thomas A. Warr, Alan D. Cherrington, John E. Liljenquist

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The possibility that somatostatin has a direct inhibitory effect on intestinal D-glucose absorption was studied in rats using intact intestinal loops and everted jejunal segments. Somatostatin infusion in vivo produced a significant fall in plasma glucose concentration (P < 0.001) and a fall in pooled plasma insulin concentration to 51% of control values. However, somatostatin infusion did not alter significantly from control values the rate of glucose disappearance from the perfused jejunal lumen in vivo or the appearance of gut-derived plasma glucose. The lack of an inhibitory effect of somatostatin on glucose absorption in vivo was confirmed using two in vitro studies. When increasing concentrations of somatostatin (0-104 ng/ml−1) were added to both mucosal and serosal solutions, no significant differences were seen for net transmural flux or unidirectional flux of D-glucose in everted jejunal segments. These studies suggest that somatostatin in the rat does not influence plasma glucose concentration by inhibiting intestinal glucose transport at physiological concentrations of glucose and over a wide range of somatostatin concentrations.

Original languageEnglish (US)
Pages (from-to)1562-1567
Number of pages6
JournalEndocrinology
Volume106
Issue number5
DOIs
StatePublished - Jan 1 1980

Fingerprint

Somatostatin
Glucose
In Vitro Techniques
Insulin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Wilson, F. A., Antonson, D. L., Hart, B. L., Warr, T. A., Cherrington, A. D., & Liljenquist, J. E. (1980). The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. Endocrinology, 106(5), 1562-1567. https://doi.org/10.1210/endo-106-5-1562

The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. / Wilson, Frederick A.; Antonson, Dean Lowell; Hart, Blaine L.; Warr, Thomas A.; Cherrington, Alan D.; Liljenquist, John E.

In: Endocrinology, Vol. 106, No. 5, 01.01.1980, p. 1562-1567.

Research output: Contribution to journalArticle

Wilson, FA, Antonson, DL, Hart, BL, Warr, TA, Cherrington, AD & Liljenquist, JE 1980, 'The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat', Endocrinology, vol. 106, no. 5, pp. 1562-1567. https://doi.org/10.1210/endo-106-5-1562
Wilson FA, Antonson DL, Hart BL, Warr TA, Cherrington AD, Liljenquist JE. The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. Endocrinology. 1980 Jan 1;106(5):1562-1567. https://doi.org/10.1210/endo-106-5-1562
Wilson, Frederick A. ; Antonson, Dean Lowell ; Hart, Blaine L. ; Warr, Thomas A. ; Cherrington, Alan D. ; Liljenquist, John E. / The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. In: Endocrinology. 1980 ; Vol. 106, No. 5. pp. 1562-1567.
@article{c3af59f26af1468e9e61ce037ff0bbe1,
title = "The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat",
abstract = "The possibility that somatostatin has a direct inhibitory effect on intestinal D-glucose absorption was studied in rats using intact intestinal loops and everted jejunal segments. Somatostatin infusion in vivo produced a significant fall in plasma glucose concentration (P < 0.001) and a fall in pooled plasma insulin concentration to 51{\%} of control values. However, somatostatin infusion did not alter significantly from control values the rate of glucose disappearance from the perfused jejunal lumen in vivo or the appearance of gut-derived plasma glucose. The lack of an inhibitory effect of somatostatin on glucose absorption in vivo was confirmed using two in vitro studies. When increasing concentrations of somatostatin (0-104 ng/ml−1) were added to both mucosal and serosal solutions, no significant differences were seen for net transmural flux or unidirectional flux of D-glucose in everted jejunal segments. These studies suggest that somatostatin in the rat does not influence plasma glucose concentration by inhibiting intestinal glucose transport at physiological concentrations of glucose and over a wide range of somatostatin concentrations.",
author = "Wilson, {Frederick A.} and Antonson, {Dean Lowell} and Hart, {Blaine L.} and Warr, {Thomas A.} and Cherrington, {Alan D.} and Liljenquist, {John E.}",
year = "1980",
month = "1",
day = "1",
doi = "10.1210/endo-106-5-1562",
language = "English (US)",
volume = "106",
pages = "1562--1567",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "5",

}

TY - JOUR

T1 - The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat

AU - Wilson, Frederick A.

AU - Antonson, Dean Lowell

AU - Hart, Blaine L.

AU - Warr, Thomas A.

AU - Cherrington, Alan D.

AU - Liljenquist, John E.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - The possibility that somatostatin has a direct inhibitory effect on intestinal D-glucose absorption was studied in rats using intact intestinal loops and everted jejunal segments. Somatostatin infusion in vivo produced a significant fall in plasma glucose concentration (P < 0.001) and a fall in pooled plasma insulin concentration to 51% of control values. However, somatostatin infusion did not alter significantly from control values the rate of glucose disappearance from the perfused jejunal lumen in vivo or the appearance of gut-derived plasma glucose. The lack of an inhibitory effect of somatostatin on glucose absorption in vivo was confirmed using two in vitro studies. When increasing concentrations of somatostatin (0-104 ng/ml−1) were added to both mucosal and serosal solutions, no significant differences were seen for net transmural flux or unidirectional flux of D-glucose in everted jejunal segments. These studies suggest that somatostatin in the rat does not influence plasma glucose concentration by inhibiting intestinal glucose transport at physiological concentrations of glucose and over a wide range of somatostatin concentrations.

AB - The possibility that somatostatin has a direct inhibitory effect on intestinal D-glucose absorption was studied in rats using intact intestinal loops and everted jejunal segments. Somatostatin infusion in vivo produced a significant fall in plasma glucose concentration (P < 0.001) and a fall in pooled plasma insulin concentration to 51% of control values. However, somatostatin infusion did not alter significantly from control values the rate of glucose disappearance from the perfused jejunal lumen in vivo or the appearance of gut-derived plasma glucose. The lack of an inhibitory effect of somatostatin on glucose absorption in vivo was confirmed using two in vitro studies. When increasing concentrations of somatostatin (0-104 ng/ml−1) were added to both mucosal and serosal solutions, no significant differences were seen for net transmural flux or unidirectional flux of D-glucose in everted jejunal segments. These studies suggest that somatostatin in the rat does not influence plasma glucose concentration by inhibiting intestinal glucose transport at physiological concentrations of glucose and over a wide range of somatostatin concentrations.

UR - http://www.scopus.com/inward/record.url?scp=0018829706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018829706&partnerID=8YFLogxK

U2 - 10.1210/endo-106-5-1562

DO - 10.1210/endo-106-5-1562

M3 - Article

VL - 106

SP - 1562

EP - 1567

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 5

ER -