The effect of myc proteins on SV40 replication in human lymphoid cells

M. Classon, M. Henriksson, G. Klein, J. Sumegi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have previously demonstrated that over-expression of c-myc facilitates the replication of SV40 DNA in human Burkitt lymphoma cells (BL). In this paper we investigated the ability of N-myc and L-myc to substitute for c-myc in promoting SV40 DNA replication. Vectors expressing either a chimeric N-myc/c-myc, N-myc or L-myc gene were constructed and co-transfected with a plasmid containing the SV40 origin of replication and the early genes encoding SV40 T antigens (Tag). The chimeric N-myc/c-myc and the N-myc proteins enhance SV40 replication in the human lymphoma line BJAB at levels comparable to c-myc. The stimulative effect of N-myc is also evident in the BL cell line RAMOS. However, L-myc stimulated SV40 replication only in RAMOS cells.

Original languageEnglish (US)
Pages (from-to)1371-1376
Number of pages6
JournalOncogene
Volume5
Issue number9
StatePublished - Oct 5 1990

Fingerprint

Burkitt Lymphoma
Lymphocytes
DNA Replication
Proto-Oncogene Proteins c-myc
Polyomavirus Transforming Antigens
Proteins
myc Genes
Replication Origin
Lymphoma
Plasmids
Cell Line
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Classon, M., Henriksson, M., Klein, G., & Sumegi, J. (1990). The effect of myc proteins on SV40 replication in human lymphoid cells. Oncogene, 5(9), 1371-1376.

The effect of myc proteins on SV40 replication in human lymphoid cells. / Classon, M.; Henriksson, M.; Klein, G.; Sumegi, J.

In: Oncogene, Vol. 5, No. 9, 05.10.1990, p. 1371-1376.

Research output: Contribution to journalArticle

Classon, M, Henriksson, M, Klein, G & Sumegi, J 1990, 'The effect of myc proteins on SV40 replication in human lymphoid cells', Oncogene, vol. 5, no. 9, pp. 1371-1376.
Classon M, Henriksson M, Klein G, Sumegi J. The effect of myc proteins on SV40 replication in human lymphoid cells. Oncogene. 1990 Oct 5;5(9):1371-1376.
Classon, M. ; Henriksson, M. ; Klein, G. ; Sumegi, J. / The effect of myc proteins on SV40 replication in human lymphoid cells. In: Oncogene. 1990 ; Vol. 5, No. 9. pp. 1371-1376.
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