Abstract
• Intestinal regeneration in patched intestinal defects is enhanced by both intestinal resection and urogastrone. Our aim was to determine if these two stimuli have synergistic effects. Ileal defects were patched with colon serosa in 45 rabbits. Group 1 (n = 11) were control subjects; group 2 (n = 12) underwent 50% intestinal resection; group 3 (n=11) received urogastrone (1.5 μg/kg per hour subcutaneously); and group 4 (n = 11) underwent intestinal resection and received urogastrone. Animals were killed at 7 and 14 days. Intestinal resection had the greater effect on epithelialization. Urogastrone inhibited contraction and intestinal resection did not. Both intestinal resection and urogastrone increased proliferative activity. Combining intestinal resection and urogastrone did not have a synergistic effect on epithelialization and diminished the effect of urogastrone on proliferation and contraction. These findings suggest that intestinal resection and urogastrone stimulate epithelialization via similar mechanisms and that urogastrone would not enhance regeneration during intestinal adaptation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1617-1621 |
| Number of pages | 5 |
| Journal | Archives of Surgery |
| Volume | 125 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1990 |
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ASJC Scopus subject areas
- Surgery
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The Effect of Intestinal Resection and Urogastrone on Intestinal Regeneration. / Thompson, Jon S; Bragg, L. E.; Saxena, S. K.
In: Archives of Surgery, Vol. 125, No. 12, 12.1990, p. 1617-1621.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Effect of Intestinal Resection and Urogastrone on Intestinal Regeneration
AU - Thompson, Jon S
AU - Bragg, L. E.
AU - Saxena, S. K.
PY - 1990/12
Y1 - 1990/12
N2 - • Intestinal regeneration in patched intestinal defects is enhanced by both intestinal resection and urogastrone. Our aim was to determine if these two stimuli have synergistic effects. Ileal defects were patched with colon serosa in 45 rabbits. Group 1 (n = 11) were control subjects; group 2 (n = 12) underwent 50% intestinal resection; group 3 (n=11) received urogastrone (1.5 μg/kg per hour subcutaneously); and group 4 (n = 11) underwent intestinal resection and received urogastrone. Animals were killed at 7 and 14 days. Intestinal resection had the greater effect on epithelialization. Urogastrone inhibited contraction and intestinal resection did not. Both intestinal resection and urogastrone increased proliferative activity. Combining intestinal resection and urogastrone did not have a synergistic effect on epithelialization and diminished the effect of urogastrone on proliferation and contraction. These findings suggest that intestinal resection and urogastrone stimulate epithelialization via similar mechanisms and that urogastrone would not enhance regeneration during intestinal adaptation.
AB - • Intestinal regeneration in patched intestinal defects is enhanced by both intestinal resection and urogastrone. Our aim was to determine if these two stimuli have synergistic effects. Ileal defects were patched with colon serosa in 45 rabbits. Group 1 (n = 11) were control subjects; group 2 (n = 12) underwent 50% intestinal resection; group 3 (n=11) received urogastrone (1.5 μg/kg per hour subcutaneously); and group 4 (n = 11) underwent intestinal resection and received urogastrone. Animals were killed at 7 and 14 days. Intestinal resection had the greater effect on epithelialization. Urogastrone inhibited contraction and intestinal resection did not. Both intestinal resection and urogastrone increased proliferative activity. Combining intestinal resection and urogastrone did not have a synergistic effect on epithelialization and diminished the effect of urogastrone on proliferation and contraction. These findings suggest that intestinal resection and urogastrone stimulate epithelialization via similar mechanisms and that urogastrone would not enhance regeneration during intestinal adaptation.
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U2 - 10.1001/archsurg.1990.01410240099020
DO - 10.1001/archsurg.1990.01410240099020
M3 - Article
C2 - 2136530
AN - SCOPUS:0025242919
VL - 125
SP - 1617
EP - 1621
JO - JAMA Surgery
JF - JAMA Surgery
SN - 2168-6254
IS - 12
ER -