The Effect of Intestinal Resection and Urogastrone on Intestinal Regeneration

Jon S Thompson, L. E. Bragg, S. K. Saxena

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

• Intestinal regeneration in patched intestinal defects is enhanced by both intestinal resection and urogastrone. Our aim was to determine if these two stimuli have synergistic effects. Ileal defects were patched with colon serosa in 45 rabbits. Group 1 (n = 11) were control subjects; group 2 (n = 12) underwent 50% intestinal resection; group 3 (n=11) received urogastrone (1.5 μg/kg per hour subcutaneously); and group 4 (n = 11) underwent intestinal resection and received urogastrone. Animals were killed at 7 and 14 days. Intestinal resection had the greater effect on epithelialization. Urogastrone inhibited contraction and intestinal resection did not. Both intestinal resection and urogastrone increased proliferative activity. Combining intestinal resection and urogastrone did not have a synergistic effect on epithelialization and diminished the effect of urogastrone on proliferation and contraction. These findings suggest that intestinal resection and urogastrone stimulate epithelialization via similar mechanisms and that urogastrone would not enhance regeneration during intestinal adaptation.

Original languageEnglish (US)
Pages (from-to)1617-1621
Number of pages5
JournalArchives of Surgery
Volume125
Issue number12
DOIs
StatePublished - Jan 1 1990

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Epidermal Growth Factor
Regeneration
Serous Membrane
Colon
Rabbits

ASJC Scopus subject areas

  • Surgery

Cite this

The Effect of Intestinal Resection and Urogastrone on Intestinal Regeneration. / Thompson, Jon S; Bragg, L. E.; Saxena, S. K.

In: Archives of Surgery, Vol. 125, No. 12, 01.01.1990, p. 1617-1621.

Research output: Contribution to journalArticle

Thompson, Jon S ; Bragg, L. E. ; Saxena, S. K. / The Effect of Intestinal Resection and Urogastrone on Intestinal Regeneration. In: Archives of Surgery. 1990 ; Vol. 125, No. 12. pp. 1617-1621.
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