The effect of different salts of saccharin on the rat urinary bladder

Ryohei Hasegawa, Samuel Monroe Cohen

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Weanling male F344 rats were fed the sodium, potassium, or calcium salf of saccharin or acid saccharin as 5% of the diet by weight for 10 weeks. Sodium saccharin induced significant urinary bladder epithelial proliferation as determined by the labelling index following [3H] thymidine incorporation and by light and scanning electron microscopic evaluation. Potassium saccharin also significantly increased the labelling index but less than the sodium salt. Calcium saccharin and acid saccharin did not significantly increase the labelling index. Similar differences were evident by light and scanning electron microscopy. These differences were not due to differences in the level of saccharin excretion in the urine following feeding of the various salts. Differences in urinary pH and urinary concentration of sodium and calcium were observed between rats fed the various forms of saccharin.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalCancer Letters
Volume30
Issue number3
DOIs
StatePublished - Mar 1986

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Saccharin
Urinary Bladder
Salts
Sodium
Potassium
Light
Acids
Inbred F344 Rats
Electron Scanning Microscopy
Thymidine
Urine
Electrons
Diet
Calcium
Weights and Measures

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The effect of different salts of saccharin on the rat urinary bladder. / Hasegawa, Ryohei; Cohen, Samuel Monroe.

In: Cancer Letters, Vol. 30, No. 3, 03.1986, p. 261-268.

Research output: Contribution to journalArticle

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