The effect of angiotensin (AH) blockade on baroreflex control of renal nerve activity in conscious rabbits with pacing-induced heart failure (HF)

H. Murakami, J. L. Liu, Irving H Zucker

Research output: Contribution to journalArticle

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Abstract

In a previous study (Circulation, 92:1-58,1995) we have shown that the baroreflex control of heart rate is significantly enhanced in rabbits with HF after administration of All (AT,) receptor antagonist. Because the control of heart rate is mediated by both sympathetic and parasympalhetic arms of autonomie nervous system we thought it necessary to investigate the role of All on the control of a pure sympathetic system in HF. Rabbits were instrumented so that we could record arterial and central venous pressure and paced for approximately 2 weeks at 360-380 bpm. A recording electrode was then placed on the left renal sympathetic nerve. Baroreflex curves were constructed in the conscious state approximately 3 days after electrode implantation. Curves were constructed before and after infusion of the AT! receptor antagonist L-158,809 (0.3 mg/kg). Unpaced rabbits were used as controls. Paced rabbits exhibited an increase in central venous pressure over control rabbits (8.3+1.3 vs. 1.1±0.4 mm Hg, respectively, p<.05>. Maximum baroreflex gain was reduced from 4.4+0.5 to 2.8+0.5 %/mm Hg (p<.05) in rabbits with HF. AT, blockade restored baroreflex sensitivity in HF rabbits (figure) but had no effect in normals. These data support the concept that All plays a role in baroreflex impairment in HF.

Original languageEnglish (US)
Pages (from-to)A596
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

Fingerprint

angiotensins
Baroreflex
Angiotensins
heart failure
nerve tissue
Heart Failure
rabbits
kidneys
Rabbits
Kidney
Central Venous Pressure
electrodes
heart rate
antagonists
Electrodes
Heart Rate
receptors
Neurology
nervous system
Nervous System

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

The effect of angiotensin (AH) blockade on baroreflex control of renal nerve activity in conscious rabbits with pacing-induced heart failure (HF). / Murakami, H.; Liu, J. L.; Zucker, Irving H.

In: FASEB Journal, Vol. 10, No. 3, 01.12.1996, p. A596.

Research output: Contribution to journalArticle

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