Abstract
Cataracts associated with diabetes and galactosemia are characterized by their rapid onset and bilateral appearance. These cataracts display similar morphology and histology and have common biochemical mechanisms initiating the cataractous processes. An understanding of these biochemical mechanisms has been aided both by the ability to reproduce these cataracts in various animal models and by the development of potent inhibitors of aldose reductase. This is a US government work. There are no restrictions on its use.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15-19 |
| Number of pages | 5 |
| Journal | Metabolism |
| Volume | 35 |
| Issue number | 4 SUPPL. 1 |
| DOIs | |
| State | Published - Apr 1986 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
The effect of aldose reductase and its inhibition on sugar cataract formation. / Kador, Peter F.; Akagi, Yoshio; Kinoshita, Jin H.
In: Metabolism, Vol. 35, No. 4 SUPPL. 1, 04.1986, p. 15-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of aldose reductase and its inhibition on sugar cataract formation
AU - Kador, Peter F.
AU - Akagi, Yoshio
AU - Kinoshita, Jin H.
PY - 1986/4
Y1 - 1986/4
N2 - Cataracts associated with diabetes and galactosemia are characterized by their rapid onset and bilateral appearance. These cataracts display similar morphology and histology and have common biochemical mechanisms initiating the cataractous processes. An understanding of these biochemical mechanisms has been aided both by the ability to reproduce these cataracts in various animal models and by the development of potent inhibitors of aldose reductase. This is a US government work. There are no restrictions on its use.
AB - Cataracts associated with diabetes and galactosemia are characterized by their rapid onset and bilateral appearance. These cataracts display similar morphology and histology and have common biochemical mechanisms initiating the cataractous processes. An understanding of these biochemical mechanisms has been aided both by the ability to reproduce these cataracts in various animal models and by the development of potent inhibitors of aldose reductase. This is a US government work. There are no restrictions on its use.
UR - http://www.scopus.com/inward/record.url?scp=0022633518&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022633518&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(86)90181-2
DO - 10.1016/0026-0495(86)90181-2
M3 - Article
C2 - 3083204
AN - SCOPUS:0022633518
VL - 35
SP - 15
EP - 19
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 4 SUPPL. 1
ER -