The early endosome

A busy sorting station for proteins at the crossroads

Marko Jovic, Mahak Sharma, Juliati Rahajeng, Steven H Caplan

Research output: Contribution to journalReview article

175 Citations (Scopus)

Abstract

Endocytosis marks the entry of internalized receptors into the complex network of endocytic trafficking pathways. Endocytic vesicles are rapidly targeted to a distinct membrane-bound endocytic organelle referred to as the early endosome. Despite the existence of numerous internalization routes, early endosomes (EE) serve as a focal point of the endocytic pathway. Sorting events initiated at this compartment determine the subsequent fate of internalized proteins and lipids, destining them either for recycling to the plasma membrane, degradation in lysosomes or delivery to the trans-Golgi network. Sorting of endocytic cargo to the latter compartments is accomplished through the formation of distinct microdomains within early endosomes, through the coordinate recruitment and assembly of the sorting machinery. An elaborate network of interactions between endocytic regulatory proteins ensures synchronized sorting of cargo to microdomains followed by morphological changes at the early endosomal membranes. Consequently, the cargo targeted either for recycling back to the plasma membrane, or for retrograde transport to the trans-Golgi network, localizes to newly-formed tubular membranes. With a high ratio of membrane surface to lumenal volume, these tubules effectively concentrate the recycling cargo, ensuring efficient transport out of the EE. Conversely, receptors sorted for degradation cluster at the flat clathrin lattices involved in invaginations of the limiting membrane, associating with newly formed intralumenal vesicles. In this review we will discuss the characteristics of early endosomes, their role in the regulation of endocytic transport, and their aberrant function in a variety of diseases.

Original languageEnglish (US)
Pages (from-to)99-112
Number of pages14
JournalHistology and Histopathology
Volume25
Issue number1
StatePublished - Jan 1 2010

Fingerprint

Endosomes
Protein Transport
Recycling
Membranes
trans-Golgi Network
Cell Membrane
Transport Vesicles
Clathrin
Endocytosis
Lysosomes
Organelles
Proteins
Lipids

Keywords

  • Disease
  • Endocytosis
  • Golgi
  • Traffic

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

The early endosome : A busy sorting station for proteins at the crossroads. / Jovic, Marko; Sharma, Mahak; Rahajeng, Juliati; Caplan, Steven H.

In: Histology and Histopathology, Vol. 25, No. 1, 01.01.2010, p. 99-112.

Research output: Contribution to journalReview article

Jovic, Marko ; Sharma, Mahak ; Rahajeng, Juliati ; Caplan, Steven H. / The early endosome : A busy sorting station for proteins at the crossroads. In: Histology and Histopathology. 2010 ; Vol. 25, No. 1. pp. 99-112.
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