The DNA damage response in filamentous fungi

Gustavo H. Goldman, Sarah Lea McGuire, Steven D Harris

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

The mechanisms used by fungal cells to repair DNA damage have been subjects of intensive investigation for almost 50 years. As a result, the model yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae have led the way in yielding critical insights into the nature of the DNA damage response. At the same time, largely through the efforts of Etta Kafer, Hirokazu Inoue, and colleagues, a substantial collection of Aspergillus nidulans and Neurospora crassa DNA repair mutants has been identified and characterized in detail. As the analysis of these mutants continues and increasing amounts of annotated genome sequence become available, it is becoming readily apparent that the DNA damage response of filamentous fungi possesses several features that distinguish it from the model yeasts. These features are emphasized in this review, which describes the genes, regulatory networks, and processes that compose the fungal DNA damage response. Further characterization of this response will likely yield general insights that are applicable to animals and plants. Moreover, it may also become evident that the DNA damage response can be manipulated to control fungal growth.

Original languageEnglish (US)
Pages (from-to)183-195
Number of pages13
JournalFungal Genetics and Biology
Volume35
Issue number3
DOIs
StatePublished - Jan 1 2002

Fingerprint

DNA Damage
Fungi
Fungal DNA
Yeasts
Aspergillus nidulans
Neurospora crassa
Schizosaccharomyces
Gene Regulatory Networks
DNA Repair
Saccharomyces cerevisiae
Genome
Growth

ASJC Scopus subject areas

  • Microbiology
  • Genetics

Cite this

Goldman, G. H., McGuire, S. L., & Harris, S. D. (2002). The DNA damage response in filamentous fungi. Fungal Genetics and Biology, 35(3), 183-195. https://doi.org/10.1006/fgbi.2002.1344

The DNA damage response in filamentous fungi. / Goldman, Gustavo H.; McGuire, Sarah Lea; Harris, Steven D.

In: Fungal Genetics and Biology, Vol. 35, No. 3, 01.01.2002, p. 183-195.

Research output: Contribution to journalReview article

Goldman, GH, McGuire, SL & Harris, SD 2002, 'The DNA damage response in filamentous fungi', Fungal Genetics and Biology, vol. 35, no. 3, pp. 183-195. https://doi.org/10.1006/fgbi.2002.1344
Goldman, Gustavo H. ; McGuire, Sarah Lea ; Harris, Steven D. / The DNA damage response in filamentous fungi. In: Fungal Genetics and Biology. 2002 ; Vol. 35, No. 3. pp. 183-195.
@article{25e17e00b30643b2b718e810e4a736ed,
title = "The DNA damage response in filamentous fungi",
abstract = "The mechanisms used by fungal cells to repair DNA damage have been subjects of intensive investigation for almost 50 years. As a result, the model yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae have led the way in yielding critical insights into the nature of the DNA damage response. At the same time, largely through the efforts of Etta Kafer, Hirokazu Inoue, and colleagues, a substantial collection of Aspergillus nidulans and Neurospora crassa DNA repair mutants has been identified and characterized in detail. As the analysis of these mutants continues and increasing amounts of annotated genome sequence become available, it is becoming readily apparent that the DNA damage response of filamentous fungi possesses several features that distinguish it from the model yeasts. These features are emphasized in this review, which describes the genes, regulatory networks, and processes that compose the fungal DNA damage response. Further characterization of this response will likely yield general insights that are applicable to animals and plants. Moreover, it may also become evident that the DNA damage response can be manipulated to control fungal growth.",
author = "Goldman, {Gustavo H.} and McGuire, {Sarah Lea} and Harris, {Steven D}",
year = "2002",
month = "1",
day = "1",
doi = "10.1006/fgbi.2002.1344",
language = "English (US)",
volume = "35",
pages = "183--195",
journal = "Fungal Genetics and Biology",
issn = "1087-1845",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - The DNA damage response in filamentous fungi

AU - Goldman, Gustavo H.

AU - McGuire, Sarah Lea

AU - Harris, Steven D

PY - 2002/1/1

Y1 - 2002/1/1

N2 - The mechanisms used by fungal cells to repair DNA damage have been subjects of intensive investigation for almost 50 years. As a result, the model yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae have led the way in yielding critical insights into the nature of the DNA damage response. At the same time, largely through the efforts of Etta Kafer, Hirokazu Inoue, and colleagues, a substantial collection of Aspergillus nidulans and Neurospora crassa DNA repair mutants has been identified and characterized in detail. As the analysis of these mutants continues and increasing amounts of annotated genome sequence become available, it is becoming readily apparent that the DNA damage response of filamentous fungi possesses several features that distinguish it from the model yeasts. These features are emphasized in this review, which describes the genes, regulatory networks, and processes that compose the fungal DNA damage response. Further characterization of this response will likely yield general insights that are applicable to animals and plants. Moreover, it may also become evident that the DNA damage response can be manipulated to control fungal growth.

AB - The mechanisms used by fungal cells to repair DNA damage have been subjects of intensive investigation for almost 50 years. As a result, the model yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae have led the way in yielding critical insights into the nature of the DNA damage response. At the same time, largely through the efforts of Etta Kafer, Hirokazu Inoue, and colleagues, a substantial collection of Aspergillus nidulans and Neurospora crassa DNA repair mutants has been identified and characterized in detail. As the analysis of these mutants continues and increasing amounts of annotated genome sequence become available, it is becoming readily apparent that the DNA damage response of filamentous fungi possesses several features that distinguish it from the model yeasts. These features are emphasized in this review, which describes the genes, regulatory networks, and processes that compose the fungal DNA damage response. Further characterization of this response will likely yield general insights that are applicable to animals and plants. Moreover, it may also become evident that the DNA damage response can be manipulated to control fungal growth.

UR - http://www.scopus.com/inward/record.url?scp=0036345968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036345968&partnerID=8YFLogxK

U2 - 10.1006/fgbi.2002.1344

DO - 10.1006/fgbi.2002.1344

M3 - Review article

VL - 35

SP - 183

EP - 195

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

SN - 1087-1845

IS - 3

ER -