The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas

A. Peralta Soler, K. A. Knudsen, M. C. Jaurand, K. R. Johnson, M. J. Wheelock, A. J.P. Klein-szanto, H. Salazar

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Malignant mesotheliomas are highly aggressive tumors that develop most frequently in the pleura of patients chronically exposed to asbestos. The distinction between malignant mesotheliomas and tumors of epithelial origin, particularly peripheral lung adenocarcinoma, can be difficult despite the use of immunocytochemical markers and other diagnostic tools. During embryonic development the cadherin cell-cell adhesion molecules participate in the segregation of cells into different tissues. As a result of complex mechanisms of tissue selectivity, N-cadherin is expressed by the developing pleural mesothelial cells and E-cadherin is expressed by the epithelial cells of the lung. Thus, we postulated that N-cadherin could be used as a marker of mesothelial cells and mesothelial tumors, in contrast to adenocarcinomas of the lung that are tumors of epithelial origin. We studied the expression of N-cadherin, E-cadherin and two cadherinassociated proteins, α-catenin and β-catenin, in 19 pleural mesotheliomas, 16 lung adenocarcinomas and in 2 mesothelioma cell lines using specific monoclonal antibodies and immunohistochemical methods. Our results show that all mesotheliomas express high levels of Ncadherin, regardless of their histological type, in contrast to lung adenocarcinomas which expressed E-cadherin but no N-cadherin. The cadherin-associated proteins, α-catenin and β-catenin, were present in both mesotheliomas and adenocarcinomas. Our results show that pleural mesotheliomas can be distinguished from lung adenocarcinomas based on the differential expression of N-cadherin and E-cadherin, using specific monoclonal antibodies and immunocytochemistry.

Original languageEnglish (US)
Pages (from-to)1363-1369
Number of pages7
JournalHuman Pathology
Volume26
Issue number12
DOIs
StatePublished - Dec 1995

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Mesothelioma
Cadherins
Catenins
Neoplasms
Adenocarcinoma of lung
Monoclonal Antibodies
Pleura
Cell Separation
Asbestos
Cell Adhesion Molecules
Embryonic Development
Adenocarcinoma
Epithelial Cells
Immunohistochemistry
Cell Line
Lung

Keywords

  • E-cadherin
  • N-cadherin
  • lung adenocarcinoma
  • mesothelioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Peralta Soler, A., Knudsen, K. A., Jaurand, M. C., Johnson, K. R., Wheelock, M. J., Klein-szanto, A. J. P., & Salazar, H. (1995). The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. Human Pathology, 26(12), 1363-1369. https://doi.org/10.1016/0046-8177(95)90302-X

The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. / Peralta Soler, A.; Knudsen, K. A.; Jaurand, M. C.; Johnson, K. R.; Wheelock, M. J.; Klein-szanto, A. J.P.; Salazar, H.

In: Human Pathology, Vol. 26, No. 12, 12.1995, p. 1363-1369.

Research output: Contribution to journalArticle

Peralta Soler, A, Knudsen, KA, Jaurand, MC, Johnson, KR, Wheelock, MJ, Klein-szanto, AJP & Salazar, H 1995, 'The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas', Human Pathology, vol. 26, no. 12, pp. 1363-1369. https://doi.org/10.1016/0046-8177(95)90302-X
Peralta Soler, A. ; Knudsen, K. A. ; Jaurand, M. C. ; Johnson, K. R. ; Wheelock, M. J. ; Klein-szanto, A. J.P. ; Salazar, H. / The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. In: Human Pathology. 1995 ; Vol. 26, No. 12. pp. 1363-1369.
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