The development of tolerance to intrathecal morphine in rat models of visceral and cutaneous pain

T. J. Ness, K. A. Follett

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The development of tolerance to intrathecal morphine was studied in rats chronically implanted with intrathecal catheters connected to osmotic minipumps. Measures of cutaneous nociception were the hot plate (HP) and tail flick (TF) tests. Measures of visceral nociception were visceromotor (VM) responses to ramped colorectal distension (CRD) and cardiovascular (CV) responses to phasic colorectal distension. Tolerance to a continuous infusion of 6 or 20 nmol/h of morphine sulfate developed over 6 days. A significant reduction in the dose-dependent effects of intrathecal morphine in the TF and HP tests and VM and CV responses to CRD occurred in rats receiving continuous infusions of morphine. The development of tolerance to intrathecal morphine was similar in both cutaneous and visceral models.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Volume248
Issue number1
DOIs
StatePublished - May 22 1998

Fingerprint

Morphine
Pain
Skin
Nociception
Tail
Catheters

Keywords

  • Colorectal
  • Intrathecal
  • Morphine tolerance
  • Nociception
  • Rat
  • Visceral

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The development of tolerance to intrathecal morphine in rat models of visceral and cutaneous pain. / Ness, T. J.; Follett, K. A.

In: Neuroscience Letters, Vol. 248, No. 1, 22.05.1998, p. 33-36.

Research output: Contribution to journalArticle

@article{41ee77769a3f4ade9b0ad43a0a3cd899,
title = "The development of tolerance to intrathecal morphine in rat models of visceral and cutaneous pain",
abstract = "The development of tolerance to intrathecal morphine was studied in rats chronically implanted with intrathecal catheters connected to osmotic minipumps. Measures of cutaneous nociception were the hot plate (HP) and tail flick (TF) tests. Measures of visceral nociception were visceromotor (VM) responses to ramped colorectal distension (CRD) and cardiovascular (CV) responses to phasic colorectal distension. Tolerance to a continuous infusion of 6 or 20 nmol/h of morphine sulfate developed over 6 days. A significant reduction in the dose-dependent effects of intrathecal morphine in the TF and HP tests and VM and CV responses to CRD occurred in rats receiving continuous infusions of morphine. The development of tolerance to intrathecal morphine was similar in both cutaneous and visceral models.",
keywords = "Colorectal, Intrathecal, Morphine tolerance, Nociception, Rat, Visceral",
author = "Ness, {T. J.} and Follett, {K. A.}",
year = "1998",
month = "5",
day = "22",
doi = "10.1016/S0304-3940(98)00327-9",
language = "English (US)",
volume = "248",
pages = "33--36",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - The development of tolerance to intrathecal morphine in rat models of visceral and cutaneous pain

AU - Ness, T. J.

AU - Follett, K. A.

PY - 1998/5/22

Y1 - 1998/5/22

N2 - The development of tolerance to intrathecal morphine was studied in rats chronically implanted with intrathecal catheters connected to osmotic minipumps. Measures of cutaneous nociception were the hot plate (HP) and tail flick (TF) tests. Measures of visceral nociception were visceromotor (VM) responses to ramped colorectal distension (CRD) and cardiovascular (CV) responses to phasic colorectal distension. Tolerance to a continuous infusion of 6 or 20 nmol/h of morphine sulfate developed over 6 days. A significant reduction in the dose-dependent effects of intrathecal morphine in the TF and HP tests and VM and CV responses to CRD occurred in rats receiving continuous infusions of morphine. The development of tolerance to intrathecal morphine was similar in both cutaneous and visceral models.

AB - The development of tolerance to intrathecal morphine was studied in rats chronically implanted with intrathecal catheters connected to osmotic minipumps. Measures of cutaneous nociception were the hot plate (HP) and tail flick (TF) tests. Measures of visceral nociception were visceromotor (VM) responses to ramped colorectal distension (CRD) and cardiovascular (CV) responses to phasic colorectal distension. Tolerance to a continuous infusion of 6 or 20 nmol/h of morphine sulfate developed over 6 days. A significant reduction in the dose-dependent effects of intrathecal morphine in the TF and HP tests and VM and CV responses to CRD occurred in rats receiving continuous infusions of morphine. The development of tolerance to intrathecal morphine was similar in both cutaneous and visceral models.

KW - Colorectal

KW - Intrathecal

KW - Morphine tolerance

KW - Nociception

KW - Rat

KW - Visceral

UR - http://www.scopus.com/inward/record.url?scp=0032557653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032557653&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(98)00327-9

DO - 10.1016/S0304-3940(98)00327-9

M3 - Article

C2 - 9665657

AN - SCOPUS:0032557653

VL - 248

SP - 33

EP - 36

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -