The development of glycine-like immunoreactivity in the dorsal cochlear nucleus

Garrett H. Riggs, Edward J. Walsh, Laura Schweitzer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Both anatomical and physiological lines of evidence suggest that inhibitory influences are active early in the development of the dorsal cochlear nucleus (DCN). Data from physiological/pharmacological studies suggest that in the adult these inhibitory influences may be mediated at least in part by the neurotransmitter glycine. Using a polyclonal antibody to examine the development of glycine in the DCN, we have observed that glycine-like immunoreactive cell bodies and punctate label are present in the DCN by the day of birth in the hamster and in the kitten at least 10 days prior to birth. In contrast to the development of immunoreactivity for glutamic acid decarboxylase (GAD) (Schweitzer et al., 1993), glycine-like immunoreactivity shows a homogeneous distribution throughout the DCN from the day of birth through adulthood. In addition, glucine immunoreactivity is present earlier than GAD-immunoreactivity and is present well before these brain structures become responsive to air-borne sounds. Thus, glycine is present in the very young animal and may mediate inhibitory effects that occur early in development.

Original languageEnglish (US)
Pages (from-to)172-180
Number of pages9
JournalHearing Research
Volume89
Issue number1-2
DOIs
StatePublished - Sep 1995

Fingerprint

Cochlear Nucleus
Glycine
Glutamate Decarboxylase
Parturition
Cricetinae
Neurotransmitter Agents
Air
Pharmacology
Antibodies
Brain

Keywords

  • Cochlear nucleus
  • Development
  • Glutamic acid decarboxylase
  • Glycine
  • Hearing
  • Inhibition

ASJC Scopus subject areas

  • Sensory Systems

Cite this

The development of glycine-like immunoreactivity in the dorsal cochlear nucleus. / Riggs, Garrett H.; Walsh, Edward J.; Schweitzer, Laura.

In: Hearing Research, Vol. 89, No. 1-2, 09.1995, p. 172-180.

Research output: Contribution to journalArticle

Riggs, Garrett H. ; Walsh, Edward J. ; Schweitzer, Laura. / The development of glycine-like immunoreactivity in the dorsal cochlear nucleus. In: Hearing Research. 1995 ; Vol. 89, No. 1-2. pp. 172-180.
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