The colorado thyroid disease prevalence study

Gay J. Canaris, Neil R. Manowitz, Gilbert Mayor, E. Chester Ridgway

Research output: Contribution to journalArticle

1569 Citations (Scopus)

Abstract

Context: The prevalence of abnormal thyroid function in the United States and the significance of thyroid dysfunction remain controversial. Systemic effects of abnormal thyroid function have not been fully delineated, particularly in cases of mild thyroid failure. Also, the relationship between traditional hypothyroid symptoms and biochemical thyroid function is unclear. Objective: To determine the prevalence of abnormal thyroid function and the relationship between (1) abnormal thyroid function and lipid levels and (2) abnormal thyroid function and symptoms using modern and sensitive thyroid tests. Design: Cross-sectional study. Participants: Participants in a statewide health fair in Colorado, 1995 (N = 25 862). Main Outcome Measures: Serum thyrotropin (thyroid-stimulating hormone [TSH]) and total thyroxine (T4) concentrations, serum lipid levels, and responses to a hypo- thyroid symptoms questionnaire. Results: The prevalence of elevated TSH levels (nor- mal range, 0.3-5.1 mlU/L) in this population was 9.5%, and the prevalence of decreased TSH levels was 2.2%. Forty percent of patients taking thyroid medications had abnormal TSH levels. Lipid levels increased in a graded fashion as thyroid function declined. Also, the mean total cholesterol and low-density lipoprotein cholesterol levels of subjects with TSH values between 5.1 and 10 mIU/L were significantly greater than the corresponding mean lipid levels in euthyroid subjects. Symptoms were reported more often in hypothyroid vs euthyroid individuals, but individual symptom sensitivities were low. Conclusions: The prevalence of abnormal biochemical thyroid function reported here is substantial and con- firms previous reports in smaller populations. Among patients taking thyroid medication, only 60% were within the normal range of TSH. Modest elevations of TSH corresponded to changes in lipid levels that may affect cardiovascular health. Individual symptoms were not very sensitive, but patients who report multiple thyroid symptoms warrant serum thyroid testing. These results confirm that thyroid dysfunction is common, may often go undetected, and may be associated with ad- verse health outcomes that can be avoided by serum TSH measurement.

Original languageEnglish (US)
Pages (from-to)526-534
Number of pages9
JournalArchives of Internal Medicine
Volume160
Issue number4
DOIs
StatePublished - Feb 28 2000

Fingerprint

Thyroid Diseases
Thyroid Gland
Cross-Sectional Studies
Thyrotropin
Lipids
Serum
Health Fairs
Health
Thyroxine

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Canaris, G. J., Manowitz, N. R., Mayor, G., & Ridgway, E. C. (2000). The colorado thyroid disease prevalence study. Archives of Internal Medicine, 160(4), 526-534. https://doi.org/10.1001/archinte.160.4.526

The colorado thyroid disease prevalence study. / Canaris, Gay J.; Manowitz, Neil R.; Mayor, Gilbert; Ridgway, E. Chester.

In: Archives of Internal Medicine, Vol. 160, No. 4, 28.02.2000, p. 526-534.

Research output: Contribution to journalArticle

Canaris, GJ, Manowitz, NR, Mayor, G & Ridgway, EC 2000, 'The colorado thyroid disease prevalence study', Archives of Internal Medicine, vol. 160, no. 4, pp. 526-534. https://doi.org/10.1001/archinte.160.4.526
Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The colorado thyroid disease prevalence study. Archives of Internal Medicine. 2000 Feb 28;160(4):526-534. https://doi.org/10.1001/archinte.160.4.526
Canaris, Gay J. ; Manowitz, Neil R. ; Mayor, Gilbert ; Ridgway, E. Chester. / The colorado thyroid disease prevalence study. In: Archives of Internal Medicine. 2000 ; Vol. 160, No. 4. pp. 526-534.
@article{493bf2e7a6464b91afbba87c20489b09,
title = "The colorado thyroid disease prevalence study",
abstract = "Context: The prevalence of abnormal thyroid function in the United States and the significance of thyroid dysfunction remain controversial. Systemic effects of abnormal thyroid function have not been fully delineated, particularly in cases of mild thyroid failure. Also, the relationship between traditional hypothyroid symptoms and biochemical thyroid function is unclear. Objective: To determine the prevalence of abnormal thyroid function and the relationship between (1) abnormal thyroid function and lipid levels and (2) abnormal thyroid function and symptoms using modern and sensitive thyroid tests. Design: Cross-sectional study. Participants: Participants in a statewide health fair in Colorado, 1995 (N = 25 862). Main Outcome Measures: Serum thyrotropin (thyroid-stimulating hormone [TSH]) and total thyroxine (T4) concentrations, serum lipid levels, and responses to a hypo- thyroid symptoms questionnaire. Results: The prevalence of elevated TSH levels (nor- mal range, 0.3-5.1 mlU/L) in this population was 9.5{\%}, and the prevalence of decreased TSH levels was 2.2{\%}. Forty percent of patients taking thyroid medications had abnormal TSH levels. Lipid levels increased in a graded fashion as thyroid function declined. Also, the mean total cholesterol and low-density lipoprotein cholesterol levels of subjects with TSH values between 5.1 and 10 mIU/L were significantly greater than the corresponding mean lipid levels in euthyroid subjects. Symptoms were reported more often in hypothyroid vs euthyroid individuals, but individual symptom sensitivities were low. Conclusions: The prevalence of abnormal biochemical thyroid function reported here is substantial and con- firms previous reports in smaller populations. Among patients taking thyroid medication, only 60{\%} were within the normal range of TSH. Modest elevations of TSH corresponded to changes in lipid levels that may affect cardiovascular health. Individual symptoms were not very sensitive, but patients who report multiple thyroid symptoms warrant serum thyroid testing. These results confirm that thyroid dysfunction is common, may often go undetected, and may be associated with ad- verse health outcomes that can be avoided by serum TSH measurement.",
author = "Canaris, {Gay J.} and Manowitz, {Neil R.} and Gilbert Mayor and Ridgway, {E. Chester}",
year = "2000",
month = "2",
day = "28",
doi = "10.1001/archinte.160.4.526",
language = "English (US)",
volume = "160",
pages = "526--534",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - The colorado thyroid disease prevalence study

AU - Canaris, Gay J.

AU - Manowitz, Neil R.

AU - Mayor, Gilbert

AU - Ridgway, E. Chester

PY - 2000/2/28

Y1 - 2000/2/28

N2 - Context: The prevalence of abnormal thyroid function in the United States and the significance of thyroid dysfunction remain controversial. Systemic effects of abnormal thyroid function have not been fully delineated, particularly in cases of mild thyroid failure. Also, the relationship between traditional hypothyroid symptoms and biochemical thyroid function is unclear. Objective: To determine the prevalence of abnormal thyroid function and the relationship between (1) abnormal thyroid function and lipid levels and (2) abnormal thyroid function and symptoms using modern and sensitive thyroid tests. Design: Cross-sectional study. Participants: Participants in a statewide health fair in Colorado, 1995 (N = 25 862). Main Outcome Measures: Serum thyrotropin (thyroid-stimulating hormone [TSH]) and total thyroxine (T4) concentrations, serum lipid levels, and responses to a hypo- thyroid symptoms questionnaire. Results: The prevalence of elevated TSH levels (nor- mal range, 0.3-5.1 mlU/L) in this population was 9.5%, and the prevalence of decreased TSH levels was 2.2%. Forty percent of patients taking thyroid medications had abnormal TSH levels. Lipid levels increased in a graded fashion as thyroid function declined. Also, the mean total cholesterol and low-density lipoprotein cholesterol levels of subjects with TSH values between 5.1 and 10 mIU/L were significantly greater than the corresponding mean lipid levels in euthyroid subjects. Symptoms were reported more often in hypothyroid vs euthyroid individuals, but individual symptom sensitivities were low. Conclusions: The prevalence of abnormal biochemical thyroid function reported here is substantial and con- firms previous reports in smaller populations. Among patients taking thyroid medication, only 60% were within the normal range of TSH. Modest elevations of TSH corresponded to changes in lipid levels that may affect cardiovascular health. Individual symptoms were not very sensitive, but patients who report multiple thyroid symptoms warrant serum thyroid testing. These results confirm that thyroid dysfunction is common, may often go undetected, and may be associated with ad- verse health outcomes that can be avoided by serum TSH measurement.

AB - Context: The prevalence of abnormal thyroid function in the United States and the significance of thyroid dysfunction remain controversial. Systemic effects of abnormal thyroid function have not been fully delineated, particularly in cases of mild thyroid failure. Also, the relationship between traditional hypothyroid symptoms and biochemical thyroid function is unclear. Objective: To determine the prevalence of abnormal thyroid function and the relationship between (1) abnormal thyroid function and lipid levels and (2) abnormal thyroid function and symptoms using modern and sensitive thyroid tests. Design: Cross-sectional study. Participants: Participants in a statewide health fair in Colorado, 1995 (N = 25 862). Main Outcome Measures: Serum thyrotropin (thyroid-stimulating hormone [TSH]) and total thyroxine (T4) concentrations, serum lipid levels, and responses to a hypo- thyroid symptoms questionnaire. Results: The prevalence of elevated TSH levels (nor- mal range, 0.3-5.1 mlU/L) in this population was 9.5%, and the prevalence of decreased TSH levels was 2.2%. Forty percent of patients taking thyroid medications had abnormal TSH levels. Lipid levels increased in a graded fashion as thyroid function declined. Also, the mean total cholesterol and low-density lipoprotein cholesterol levels of subjects with TSH values between 5.1 and 10 mIU/L were significantly greater than the corresponding mean lipid levels in euthyroid subjects. Symptoms were reported more often in hypothyroid vs euthyroid individuals, but individual symptom sensitivities were low. Conclusions: The prevalence of abnormal biochemical thyroid function reported here is substantial and con- firms previous reports in smaller populations. Among patients taking thyroid medication, only 60% were within the normal range of TSH. Modest elevations of TSH corresponded to changes in lipid levels that may affect cardiovascular health. Individual symptoms were not very sensitive, but patients who report multiple thyroid symptoms warrant serum thyroid testing. These results confirm that thyroid dysfunction is common, may often go undetected, and may be associated with ad- verse health outcomes that can be avoided by serum TSH measurement.

UR - http://www.scopus.com/inward/record.url?scp=0034723754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034723754&partnerID=8YFLogxK

U2 - 10.1001/archinte.160.4.526

DO - 10.1001/archinte.160.4.526

M3 - Article

C2 - 10695693

AN - SCOPUS:0034723754

VL - 160

SP - 526

EP - 534

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 4

ER -